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Study of cathelicidin (LL-37) immunoexpression in the skin of vitiligo patients.
Arch Dermatol Res
January 2025
Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Vitiligo is a pigmentary disorder acquired and caused by the loss or destruction of melanocytes from the epidermis. There is strong proof that vitiligo is mainly an autoimmune disease. Cathelicidin (LL37), an antimicrobial polypeptide, is an important part of the innate immune system and has a role in different skin autoimmune diseases.
View Article and Find Full Text PDFSensory Symptoms as an Early Manifestation of Active Vitiligo: A Case-Control Clinical and Molecular Study.
Pigment Cell Melanoma Res
January 2025
Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
Vitiligo pathogenesis is complex. There is some evidence in support of the neurohormonal pathways involved. Although considered a nonpruritic condition, some patients may experience itching, which can occur ahead of the appearance of the patches.
View Article and Find Full Text PDFComorbidities Associated with Vitiligo: Results from the EpiChron Cohort.
J Clin Med
January 2025
Department of Dermatology, Miguel Servet University Hospital IIS Aragon, 50009 Zaragoza, Spain.
Vitiligo is a pigmentation disorder that impacts approximately 0.5% to 2% of the global population. Growing interest surrounds the comorbidities associated with vitiligo.
View Article and Find Full Text PDFEVALUATION OF VITAMIN D LEVEL IN SERUM OF PATIENTS WITH VITILIGO.
Georgian Med News
November 2024
2Department of Pharmacology, College of Medicine, University of Baghdad, Iraq.
Background: Vitamin D deficiency promotes initiation and sustainment of numerous medical disorders, including cancer, diabetes mellitus, autoimmune disorders, and cardiovascular diseases. The expression of vitamin D receptors by melanocytes suggests a role for it in controlling their physiology.
Aim: Therefore, the aim of this study was to compare serum vitamin D levels in patients with vitiligo and normal healthy individuals.
Di-Genic Inheritance in Genodermatoses: Insights from Two Consanguineous Cases in a Reference Lebanese Center within the Middle East and North Africa (MENA) Region.
Dermatol Pract Concept
January 2025
Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Introduction: Genodermatoses refer to a group of heterogenous rare genetic diseases with cutaneous expression. Several genodermatoses present with multisystem involvement that can range from mild to life-threatening conditions leading to increased morbidity and mortality.
Objective: Given the paucity in the literature in the field of genodermatoses, especially in the Middle East and North Africa (MENA) region, and building upon the first established genodermatoses database based in Lebanon, this study aimed to decipher the genetic basis of two different types of skin-inherited diseases (androgenic alopecia and vitiligo).
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