The present study examined laparoscopic skill acquisition on a simulator for different sequences of open and closed loop tasks. Sixteen medical students were divided into four groups distinguished by their initial training task and subsequent transfer task. Group 1 practiced instrument navigation, an open loop task, and then transferred to grasping, a closed loop task. Group 2 practiced grasping, and then transferred to the instrument navigation task. Group 3 practiced instrument navigation and then transferred to a complex cutting task that involved both open and closed loop components. Group 4 practiced grasping and then transferred to the cutting task. The results showed distinct task sequencing effects in favor of initial practice on a closed loop task. Specifically, task completion times declined significantly when participants practiced the closed loop task followed by the open loop task. The benefits of initial practice on a closed loop task, however, were limited primarily to accuracy measures when participants transferred to the complex cutting task. The findings indicate that task order is important and that training on one task can either facilitate or impede skill acquisition on a subsequent task and that these differences reflect fundamental psychomotor characteristics of the tasks.
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J Hazard Mater
January 2025
Hubei Three Gorges Laboratory, Yichang 443000, China.
With the global surge in lithium-ion batteries (LIBs), recycling spent LIBs has become an essential and urgent research area. In the context of global efforts to promote sustainable development, and achieve energy conservation and emission reduction, advancing recycling technologies that efficiently recover critical metals like Ni, Co, Mn, and Li is crucial. Herein, a novel and environmentally friendly simplified process for selectively extracting critical metals from the mixed electrode materials of spent LIBs is proposed for the first time.
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January 2025
Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas, USA.
Unlabelled: Human norovirus (HuNoV) is a leading cause of gastroenteritis worldwide and is associated with significant morbidity, mortality, and economic impact. There are currently no licensed antiviral drugs for the treatment of HuNoV-associated gastroenteritis. The HuNoV protease plays a critical role in the initiation of virus replication by cleaving the polyprotein.
View Article and Find Full Text PDFProtein Sci
February 2025
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
We have recently demonstrated a novel anaerobic NADH-dependent haem breakdown reaction, which is carried out by a range of haemoproteins. The Yersinia enterocolitica protein, HemS, is the focus of further research presented in the current paper. Using conventional experimental methods, bioinformatics, and energy landscape theory (ELT), we provide new insight into the mechanism of the novel breakdown process.
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January 2025
Department of Otorhinolaryngology-Head & Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Introduction: Prolonged psychological stress is closely associated with cancer due to its role in promoting the release of stress hormones through the sustained activation of the sympathetic-adrenal-medullary system. These hormones interact with receptors on inflammatory cells, leading to the activation of key signaling pathways, including the transcription factors signal transducer and activator of transcription 3 (STAT-3) and kappa-light-chain-enhancer of activated B cells (NF-κB). These factors drive the production of pro-inflammatory substances, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which can influence the initiation and progression of cancer.
View Article and Find Full Text PDFCardiovasc Eng Technol
January 2025
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, MA, Cambridge, USA.
Purpose: Atrial fibrillation (AF) is the most common chronic cardiac arrhythmia that increases the risk of stroke, primarily due to thrombus formation in the left atrial appendage (LAA). Left atrial appendage occlusion (LAAO) devices offer an alternative to oral anticoagulation for stroke prevention. However, the complex and variable anatomy of the LAA presents significant challenges to device design and deployment.
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