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Three-Axis Vibration Isolation of a Full-Scale Magnetorheological Seat Suspension.
Micromachines (Basel)
November 2024
InnoVital Systems Inc., Calverton, MD 20705, USA.
This study examines the three-axis vibration isolation capabilities of a full-scale magnetorheological (MR) seat suspension system utilizing experimental methods to assess performance under both single-axis and simultaneous three-axis input conditions. To achieve this, a semi-active MR seat damper was designed and manufactured to address excitations in all three axes. The damper effectiveness was tested experimentally for axial and lateral motions, focusing on dynamic stiffness and loss factor using an MTS machine.
View Article and Find Full Text PDFPotential of phosphodiesterase 4B inhibition in the treatment of progressive pulmonary fibrosis.
Ther Adv Respir Dis
January 2025
University of Texas Health San Antonio and the South Texas Veterans Health Care System, San Antonio, TX, USA.
Idiopathic pulmonary fibrosis (IPF) is often regarded as the archetypal progressive fibrosing interstitial lung disease (ILD). The term "progressive pulmonary fibrosis" (PPF) generally describes progressive lung fibrosis in an individual with an ILD other than IPF. Both IPF and PPF are associated with loss of lung function, worsening dyspnea and quality of life, and premature death.
View Article and Find Full Text PDFThe Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis.
Drug Des Devel Ther
June 2024
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, People's Republic of China.
Article Synopsis
- - Psoriasis is a common, chronic skin disease that negatively impacts both physical and mental health, leading to significant suffering and high health care costs; the treatment PSORI-CM01 has shown effectiveness over years of clinical use, though its exact mechanisms are not well understood.
- - Research involving network pharmacology and microRNA profiling identified that PSORI-CM01 improves psoriasis symptoms by regulating autophagy, apoptosis, and inflammatory responses, specifically affecting key microRNAs like miR-20a-3p and miR-3184-3p.
- - Experimental findings confirmed that PSORI-CM01 treatment leads to changes in gene expression linked to these microRNAs, enhancing autophagy and affecting pathways related to inflammation and cell growth
Giant honeybees (Apis dorsata) trade off defensiveness against periodic mass flight activity.
PLoS One
April 2024
Institute of Biology, University of Graz, Graz Austria.
The giant honeybee Apis dorsata (Fabricius, 1793) is an evolutionarily ancient species that builds its nests in the open. The nest consists of a single honeycomb covered with the bee curtain which are several layers of worker bees that remain almost motionless with their heads up and abdomens down on the nest surface, except for the mouth area, the hub between inner- and outer-nest activities. A colony may change this semi-quiescence several times a day, depending on its reproductive state and ambient temperature, to enter the state of mass flight activity (MFA), in which nest organisation is restructured and defense ability is likely to be suppressed (predicted by the mass-flight-suspend-defensiveness hypothesis).
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