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Primary cutaneous melioidosis - A rare case needing intensive care unit admission.
South Afr J Crit Care
July 2024
Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Background: Melioidosis cases are increasing in Southeast Asia, posing a significant challenge owing to the rising number of diabetic and immune compromised patients. Pneumonia is the most common presentation of melioidosis, while cutaneous melioidosis is rare.
Objectives: We report a case of primary cutaneous melioidosis (PCM) that eventually required intensive care unit (ICU) management.
Meropenem-resistant Burkholderia pseudomallei: a concerning single case in Australia with no prior meropenem exposure.
Access Microbiol
October 2024
Pathology Queensland, Townsville Hospital, Douglas, Townsville, Queensland, Australia.
We report a case of cutaneous melioidosis in a 54-year-old male with a meropenem-resistant sub-population. He was empirically treated with episodic doxycycline and trimethoprim-sulfamethoxazole; however, the abscess re-accumulated. The patient had no prior exposure to meropenem.
View Article and Find Full Text PDFAdverse reactions to trimethoprim/sulfamethoxazole for melioidosis eradication therapy: An evaluation of frequency and risk factors.
Int J Infect Dis
January 2025
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Infectious Diseases Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Trimethoprim/sulfamethoxazole is the first-line agent for oral eradication therapy for melioidosis but has been associated with toxicity in this context. This study aimed to quantify adverse drug reactions (ADRs) to trimethoprim/sulfamethoxazole when used for treatment of melioidosis, and assess risk factors for ADR development. A retrospective review of antimicrobial associated ADRs was performed in all patients treated for melioidosis in the Northern Territory of Australia from January 2017-September 2022.
View Article and Find Full Text PDFCase Report: Melioidosis-Related Severe Cutaneous Features of Erythema Nodosum in a Thai Child.
Am J Trop Med Hyg
January 2024
Pediatric Division, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Erythema nodosum (EN) is characterized by rapidly developing, painful, erythematous subcutaneous nodules, most of which are located in the pretibial areas. This cutaneous finding can be caused by a variety of conditions, however Burkholderia pseudomallei is rarely the cause. This particular patient presented with a high-grade fever with characteristic EN on both pretibial areas.
View Article and Find Full Text PDFMelioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease.
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