Purpose: To develop a combined SPECT/CT based on a conventional gamma camera with the following design goals: (i) the subject is scanned on the same bed without moving between SPECT and CT scans, (ii) maintenance of full diagnostic utility of both scanners, (iii) a minimal equipment footprint which is adaptable to different site configurations, (iv) a modular design so that either scanner can be upgraded without impacting the other scanner and (v) cost-effectiveness.
Methods: A Philips SKYLight gamma camera was combined with a single-slice helical CT. The CT bed has been modified by mounting on wheels and is attached to a track in the floor when required. The CT bed is used for both the CT and the SPECT scans. The CT bed is parked outside the SKYLight's active area when not required. The CT data are used for anatomical localisation, attenuation correction and definition of anatomical boundaries (e.g. lobar boundaries in the lungs).
Results: The combined SPECT/CT system is installed in a 6.2 mx4.6 m room. The CT can scan up to 1.3 m of the subject, which is usually sufficient for registration with the SPECT scan. More than 200 subjects have had SPECT/CT scans in the first year of operation. Initially, the main outcome has been improved confidence of localisation of abnormalities. Attenuation correction for all relevant radionuclides has been implemented.
Conclusion: We have developed a combined SPECT/CT using a novel approach based on a low-cost CT scanner. The design is compact, is readily upgradeable and does not compromise either machine's diagnostic or functional capabilities.
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http://dx.doi.org/10.1007/s00259-006-0364-3 | DOI Listing |
Mol Pharm
January 2025
Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Acute myocardial infarction (MI) remains a leading cause of mortality worldwide, with inflammatory and reparative phases playing critical roles in disease progression. Currently, there is a pressing need for imaging techniques to monitor immune cell infiltration and inflammation activity during these phases. We developed a novel probe, Tc-HYNIC-mAb, utilizing a monoclonal antibody that targets the voltage-gated potassium channel 1.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Department of Nuclear Medicine and Molecular Imaging, Institut de Cancérologie de Strasbourg Europe (ICANS), University Hospitals of Strasbourg, University of Strasbourg, 67200 Strasbourg, France.
Patients diagnosed with multiple endocrine neoplasia type-1 (MEN1) often initially present with primary hyperparathyroidism (pHPT), and typically undergo surgical intervention. While laboratory tests are fundamental for diagnosis, imaging is crucial for localizing pathological parathyroids to aid in precise surgical planning. In this pictorial review, we will begin by comprehensively examining key imaging techniques and their established protocols, evaluating their effectiveness in detecting abnormal parathyroid glands.
View Article and Find Full Text PDFEur Thyroid J
January 2025
G Treglia, Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Background: In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium-iodine symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by [131/123I]Iodine whole-body scan. However, these approaches have low sensitivity due to the low sensitivity due to the low resolution of SPECT. [18F]Tetrafluoroborate (TFB) has been proposed as a viable alternative, which could outperform [131/123I]Iodine scans owing to the superior PET resolution.
View Article and Find Full Text PDFCureus
December 2024
Department of Pediatrics, Division of Neonatology, Blythedale Children's Hospital, Valhalla, USA.
Retroperitoneal teratomas are rare neoplasms in neonates, presenting with nonspecific symptoms and variable clinical features, making diagnosis challenging. Radiological investigations, particularly fetal ultrasound and contrast-enhanced computed tomography, play a critical role in their detection. Differential diagnoses include neuroblastoma, adrenal hemorrhage, and congenital cystic lesions, which share overlapping clinical and imaging features.
View Article and Find Full Text PDFThe article presents a clinical case of secondary cardiomyopathy in an HIV patient with plasmablastic lymphoma due to the combined pathology (HIV infection with ongoing antiretroviral therapy in combination with antitumor therapy), in which the use of multimodal imaging contributed to establishing the correct diagnosis and excluding the unjustified use of invasive methods for diagnosing ischemic heart disease.
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