Background: The relationship between cholera and climate was explored in Africa, the continent with the most reported cases, by analyzing monthly 20-year cholera time series for five coastal adjoining West African countries: Côte d'Ivoire, Ghana, Togo, Benin and Nigeria.
Methods: We used wavelet analyses and derived methods because these are useful mathematical tools to provide information on the evolution of the periodic component over time and allow quantification of non-stationary associations between time series.
Results: The temporal variability of cholera incidence exhibits an interannual component, and a significant synchrony in cholera epidemics is highlighted at the end of the 1980's. This observed synchrony across countries, even if transient through time, is also coherent with both the local variability of rainfall and the global climate variability quantified by the Indian Oscillation Index.
Conclusion: Results of this study suggest that large and regional scale climate variability influence both the temporal dynamics and the spatial synchrony of cholera epidemics in human populations in the Gulf of Guinea, as has been described for two other tropical regions of the world, western South America and Bangladesh.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839095 | PMC |
| http://dx.doi.org/10.1186/1471-2334-7-20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Strain variation and anomalous climate synergistically influence cholera pandemics.
PLoS Negl Trop Dis
August 2024
Department of Biology and Department of Environmental Sciences, New York University, New York City, New York, United States of America.
Background: Explanations for the genesis and propagation of cholera pandemics since 1817 have remained elusive. Evolutionary pathogen change is presumed to have been a dominant factor behind the 7th "El Tor" pandemic, but little is known to support this hypothesis for preceding pandemics. The role of anomalous climate in facilitating strain replacements has never been assessed.
View Article and Find Full Text PDFReplication termination without a replication fork trap.
Sci Rep
June 2019
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Université Paris Sud, Gif sur Yvette, France.
Bacterial chromosomes harbour a unique origin of bidirectional replication, oriC. They are almost always circular, with replication terminating in a region diametrically opposite to oriC, the terminus. The oriC-terminus organisation is reflected by the orientation of the genes and by the disposition of DNA-binding protein motifs implicated in the coordination of chromosome replication and segregation with cell division.
View Article and Find Full Text PDFStringent response leads to continued cell division and a temporal restart of DNA replication after initial shutdown in Vibrio cholerae.
Mol Microbiol
June 2019
LOEWE Center for Synthetic Microbiology - SYNMIKRO, Philipps-Universität Marburg, Marburg, Germany.
Vibrio cholerae is an aquatic bacterium with the potential to infect humans and cause the cholera disease. While most bacteria have single chromosomes, the V. cholerae genome is encoded on two replicons of different size.
View Article and Find Full Text PDFSynchronous termination of replication of the two chromosomes is an evolutionary selected feature in Vibrionaceae.
PLoS Genet
March 2018
LOEWE Center for Synthetic Microbiology-SYNMIKRO, Philipps-Universität Marburg, Marburg, Germany.
Vibrio cholerae, the causative agent of the cholera disease, is commonly used as a model organism for the study of bacteria with multipartite genomes. Its two chromosomes of different sizes initiate their DNA replication at distinct time points in the cell cycle and terminate in synchrony. In this study, the time-delayed start of Chr2 was verified in a synchronized cell population.
View Article and Find Full Text PDFA Study of Patterns of Platelet Counts in Alcohol Withdrawal.
Indian J Psychol Med
January 2017
Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Navi Mumbai, Maharashtra, India.
Aims: This study aimed to evaluate the patterns of platelet counts during the course of alcohol withdrawal and its relationship if any with liver enzymes.
Methodology: Forty consecutive patients, with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-fourth edition, Text Revision criteria, willing for a 10-day inpatient detoxification program and presenting within 12 h of the last consumption of alcohol were recruited in the study. Details about the diagnosis and alcohol consumption patterns were assessed with a detailed psychiatric interview.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!