Negative potentials evoked by painful electrical stimulation of the sural nerve that occur at 100-180 ms poststimulus over the contralateral temporal scalp (CTN100-180) and at 130-200 ms over the fronto-central scalp (FCN130-200) exhibit unusual attention effects. That is, their amplitudes are larger when the painful evoking stimulus is unattended than when it is attended. In this experiment, I show that attention has no effect on the CTN100-180 evoked by a weak, nonthreatening sural nerve electrical stimulus. These data suggest that the generators of the CTN100-180, which include the somatosensory association areas in the parietal operculum, are specifically involved in detecting threatening somatosensory stimuli. The FCN130-200 showed a small increase in the unattended condition, which is consistent with the role of its medial prefrontal cortex generators in monitoring any situation that might require a change in attentional control.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1469-8986.2006.00491.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modulation of multisensory nociceptive neurons in monkey cortical area 7b and behavioral correlates.
J Neurophysiol
August 2024
Department of Anesthesiology and Pain Medicine, School of Medicine, University of Washington, Seattle, Washington, United States.
Wide-range thermoreceptive neurons (WRT-EN) in monkey cortical area 7b that encoded innocuous and nocuous cutaneous thermal and threatening visuosensory stimulation with high fidelity were studied to identify their multisensory integrative response properties. Emphasis was given to characterizing the spatial and temporal effects of threatening visuosensory input on the thermal stimulus-response properties of these multisensory nociceptive neurons. Threatening visuosensory stimulation was most efficacious in modulating thermal evoked responses when presented as a downward ("looming"), spatially congruent, approaching and closely proximal target in relation to the somatosensory receptive field.
View Article and Find Full Text PDFChronic pain for rheumatological disorders: Pathophysiology, therapeutics and evidence.
Joint Bone Spine
December 2024
Departments of Anesthesiology, Physical Medicine & Rehabilitation, Neurology, Psychiatry and Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Departments of Anesthesiology & Critical Care Medicine, Neurology, Physical Medicine & Rehabilitation and Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Departments of Physical Medicine & Rehabilitation and Anesthesiology, Walter Reed National Military Medical Center, Uniformed Services, University of the Health Sciences, Bethesda, MD,USA. Electronic address:
Article Synopsis
- Pain is primarily why people visit orthopedic and rheumatological specialists, with types classified as nociceptive, neuropathic, or nociplastic, affecting treatment approaches.
- Effective pain management should involve a multidisciplinary approach, combining physical therapy, psychotherapy, and appropriate medications, depending on the pain type.
- Surgery is usually reserved for patients who don’t respond to conservative treatments, as certain factors like disease burden or multiple pain conditions can lead to procedural failure.
Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain.
Front Toxicol
April 2024
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Acute intoxication with high levels of organophosphate (OP) cholinesterase inhibitors can cause cholinergic crisis, which is associated with acute, life-threatening parasympathomimetic symptoms, respiratory depression and seizures that can rapidly progress to status epilepticus (SE). Clinical and experimental data demonstrate that individuals who survive these acute neurotoxic effects often develop significant chronic morbidity, including behavioral deficits. The pathogenic mechanism(s) that link acute OP intoxication to chronic neurological deficits remain speculative.
View Article and Find Full Text PDFThe ventromedial prefrontal cortex in response to threat omission is associated with subsequent explicit safety memory.
Sci Rep
March 2024
Institute of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany.
In order to memorize and discriminate threatening and safe stimuli, the processing of the actual absence of threat seems crucial. Here, we measured brain activity with fMRI in response to both threat conditioned stimuli and their outcomes by combining threat learning with a subsequent memory paradigm. Participants (N = 38) repeatedly saw a variety of faces, half of which (CS+) were associated with an aversive unconditioned stimulus (US) and half of which were not (CS-).
View Article and Find Full Text PDFOxyberberine protects middle cerebral artery occlusion triggered cerebral injury through TLR4/NLRP3 pathway in rats.
J Chem Neuroanat
March 2024
Department of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India. Electronic address:
Cerebral ischemia is a life-threatening health concern that leads to severe neurological complications and fatalities worldwide. Although timely intervention with clot-removing agents curtails serious post-stroke neurological dysfunctions, no effective neuroprotective intervention is available for addressing post-recanalization neuroinflammation. Herein, for the first time we studied the effect of oxyberberine (OBB), a derivative of berberine, on transient middle cerebral artery occlusion (MCAO)-generated neurological consequences in Sprague-Dawley rats.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!