AI Article Synopsis
- The study examines how ethanol affects the secretion of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP-1) in rat liver cells, showing that increased ethanol leads to higher IGF-I levels and inhibited IGFBP-1 secretion.
- Ethanol treatment also activates p42/44 mitogen-activated protein kinase (MAPK) activity, which plays a key role in the observed changes in IGF-I and IGFBP-1 secretion.
- Inhibitors like 4-methylpyrazole and PD98059 successfully blocked the effects of ethanol on IGF-I and IGFBP-1 secretion, indicating that p42/44 MAPK activity
Article Abstract
This article investigates the effects of ethanol on Insulin-like growth factor (IGF)-I secretion, p42/44 mitogen-activated protein kinase (MAPK) activity, and IGF binding protein (IGFBP-1 secretion) in primary cultured rat hepatocytes. The p42/44 MAPK activity increased with the ethanol concentration compared to control after ethanol treatment. The secretion of IGF-I significantly increased compared to control, but IGFBP-1 secretion was inhibited. Treatment with 4-methylpyrazole blocked the IGF-I and IGFBP-1 secretion and p42/44 MAPK activity. Increased IGF-I secretion and inhibited IGFBP-1 secretion due to ethanol-induced p42/44 MAPK activity (at 30 min) was blocked by treatment with PD98059. Taken together, these results suggest that ethanol is involved in the modulation of the secretion of IGF-I and IGFBP-1 by p42/44 MAPK in primary cultured rat hepatocytes. In addition, inhibition of p42/44 MAPK activity by ethanol occurs via the activity of ADH.
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| http://dx.doi.org/10.1080/00207450600582363 | DOI Listing |
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