AI Article Synopsis
- The paper discusses methods for creating mutant hemoglobins that have varying abilities to bind oxygen and ones that can form large aggregates to minimize problems like blood vessel leakage.
- In experiments with mice, these polymeric hemoglobins didn’t cause blood vessel reactions when used in transfusions.
- Additionally, these polymeric hemoglobins effectively deliver oxygen to tissues lacking sufficient blood supply, regardless of their oxygen-binding characteristics.
Article Abstract
This paper describes the approaches we have taken to construct a) mutant hemoglobins with different oxygen affinities, and b) mutant hemoglobins and myoglobins that polymerize to high molecular weight aggregates in an effort to prevent extravasation and the associated vasoactivity. In vivo testing indicates that exchange transfusion of polymeric hemoglobins in mice does not result in vasoactivity and that polymeric hemoglobins are effective oxygen carriers to ischemic tissues irrespective of their oxygen affinity and cooperativity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483405 | PMC |
| http://dx.doi.org/10.1080/10731190600974467 | DOI Listing |
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