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Piezo1 overexpression in the uterus contributes to myometrium contraction and inflammation-associated preterm birth.
J Transl Med
December 2024
Department of Anesthesiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South of Renmin Road, Chengdu, 610041, Sichuan, China.
Background: Preterm birth, a leading cause of perinatal mortality and morbidity, is often associated with inflammation and aberrant myometrial contractions. This study investigates the role of Piezo1, a mechanosensitive ion channel, in myometrium contraction and inflammation-associated preterm birth.
Methods: We employed Western blotting, Immunofluorescence, and Quantitative real-time PCR techniques to examine Piezo1 expression in uterine tissues.
AMPK-mTOR pathway modulates glycolysis reprogramming in unexplained recurrent spontaneous abortion.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics and Gynecology, The First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian, 350005, P.R. China.
Background: Recurrent spontaneous abortion (RSA), whose underlying cause has yet to be fully elucidated, is often classified as unexplained recurrent spontaneous abortion (URSA). Promoting the differentiation of CD4 T cells into Tregs may be the key to prevent URSA. The differentiation of CD4 T cells was controlled by mTOR, but the regulatory mechanism is still unclear.
View Article and Find Full Text PDFA case report of adenomyosis-induced spontaneous rupture in an unscarred and unpregnant uterus.
Medicine (Baltimore)
December 2024
Department of Ultrasound, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Rationale: Spontaneous uterine rupture, although rare, is a life-threatening obstetric emergency with a high maternal and fetal mortality rate. It can occur without warning, leading to severe complications, including hemorrhage, shock, and fetal demise. The risk factors contributing to uterine rupture are diverse and include a history of uterine surgery (such as cesarean section), trauma to the uterus, abnormal uterine contractions during labor, and underlying conditions like adenomyosis.
View Article and Find Full Text PDFRelationships between Fetal and Neonatal Outcomes and Spectrum of COVID-19 Disease in Pregnant Women.
Tanaffos
January 2024
Department of Epidemiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran.
Background: Due to the high prevalence of COVID-19 and the prevention and control of adverse fetal and neonatal outcomes in pregnant women, including vertical transmission, this study was performed to describe the fetal and neonatal outcomes of pregnancy with a spectrum of COVID-19 disease during pregnancy in Iran.
Materials And Methods: In this cross-sectional study, we analyzed the medical records of 258 pregnant women admitted to the Forghani Hospital, Qom, Iran, from 18 February 2020, to May 10, 2021. PCR-RT or respiratory compromise in the presence of marked radiographic changes of COVID-19 in the lungs, or both COVID-19 disease confirmed COVID-19 disease.
Preterm-birth-prevention with Lactobacillus Crispatus oral probiotics: Protocol for a double blinded randomised placebo-controlled trial (the PrePOP study).
Contemp Clin Trials
December 2024
UCD Perinatal Research Centre, UCD School of Medicine, University College Dublin, National Maternity Hospital, Dublin 2, Ireland; National Maternity Hospital, Dublin 2, Ireland. Electronic address:
Introduction: Effective spontaneous preterm birth (sPTB) prevention is an urgent unmet clinical need. Vaginal depletion of Lactobacillus crispatus is linked to sPTB. This trial will investigate impact of an oral Lactobacillus spp.
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