The modulatory effect of ionophoretic application of substance P to the skin on the formation of the cold-triggered thermal protection reactions depends on the rate of cooling. During rapid cooling substance P enhances heat production, while during slow cooling it promotes constriction of skin blood vessels aimed at reduction of heat emission.
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| http://dx.doi.org/10.1007/s10517-006-0255-4 | DOI Listing |
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