AI Article Synopsis
- The study focused on how implantation affects T lymphocyte changes in the blood and endometrium of pregnant sows.
- Researchers used flow cytometry and immunohistochemistry to analyze T-cell subsets in sows at various stages of pregnancy.
- Results showed that T cells peaked during implantation, particularly Tc and Th cells, while the number of gamma-delta T lymphocytes was minor and unaffected by implantation.
Article Abstract
Problem: We assessed implantation-associated quantitative changes in peripheral blood and endometrial T lymphocytes throughout epitheliochorial placenta formation.
Method Of Study: T-cell subsets were investigated in 10-, 15-, 20-, 30-, and 40-day pregnant and non-pregnant sows by flow cytometry and immunohistochemistry.
Results: Endometrial total T, T cytotoxic (Tc), and T helper (Th) cells were in peak numbers at the attachment phase of implantation and Tc cells persisted in high proportions up to placental establishment. The number of gammadelta T lymphocytes was relatively small and implantation-independent. In situ, T cells increased in number with the advancement of implantation and formed T-cell clusters with implantation phase-dependent location. Percentages of peripheral blood T cells were not significantly changed throughout the implantation.
Conclusion: Superficial and adeciduate implantation of pigs has a profound effect on the number of total T, Tc, and Th cells and pattern of distribution of endometrial T cells in situ.
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| http://dx.doi.org/10.1111/j.1600-0897.2007.00472.x | DOI Listing |
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