The C-banding pattern and the size and location of the nucleolar organizer regions (NORs) are described for the first time in Brazilian populations of Anopheles (Nyssorhynchus) albitarsis sensu lato. C-banding revealed variation in the size of the centromeric heterochromatic blocks in autosomal chromosomes and in the acrocentric (X) and puntiform (Y) sex chromosomes. Fluorescence in situ hybridization showed that the NORs were located in the pericentromeric region of the sex (XX/XY) chromosomes and that this coincided with the number and location of centromeric constitutive heterochromatin blocks previously revealed by C-banding. The NORs varied in size among the homologues of the three populations. These findings of the populations studied support the hypothesis that the stability of NORs in the A. albitarsis complex is characterized by the presence of clustered and conserved sites in a unique pair of chromosomes.
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http://dx.doi.org/10.1111/j.2006.0018-0661.01926.x | DOI Listing |
Alzheimers Dement
December 2024
Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Background: In various neurological disorders, including Alzheimer's disease (AD) and AD-related dementia, there is a notable reduction in gamma-aminobutyric acid (GABA)ergic neurons, which represent the most abundant inhibitory neurons in the human brain. This study explores molecular association between miR-502-3p and the function of GABAergic neurons in AD.
Method: The investigation commenced by examining the status of GABA receptor proteins and miR-502-3p in postmortem AD brains.
Alzheimers Dement
December 2024
Center for Alzheimer's Disease Research, Providence, RI, USA.
Background: Retrotransposon-derived extrachromosomal circular DNA (eccDNA) was extracted and sequenced from brains with Alzheimer's disease, progressive supranuclear palsy, or healthy controls. Retrotransposon-derived DNA was visualized outside of the nucleus in these phenotypes with phospho-STING. Drosophila were used as a model to study extranuclear retrotransposon DNA.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide and is characterized by clinical symptoms that include deficits in memory and cognition. There is an urgent need to better identify the neural networks that govern cognitive processes in humans and how they are impacted by AD pathology. The brainstem is a critical region that 'connects' the forebrain and the spinal cord and contains various nuclei involved in autonomic and complex functions (e.
View Article and Find Full Text PDFAndrology
January 2025
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
Background: 6-Nitrodopamine (6-ND) released from rat vas deferens acts an endogenous modulator of vas deferens contractility.
Objectives: To investigate whether rat isolated seminal vesicles (RISV) releases 6-ND, the mechanisms involved in the release, and the modulatory role of 6-ND on tissue contractility.
Methods: Rat seminal vesicles were removed and placed in Krebs-Henseleit's solution at 37°C for 30 min, and an aliquot was used to analyze the concentrations of 6-ND, dopamine, noradrenaline, and adrenaline by liquid chromatography with tandem mass spectrometry (LC-MS/MS).
Indian J Pathol Microbiol
January 2025
Department of Oncopathology, Mahamana Pandit Madan Mohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India.
ALK-positive large B-cell lymphoma (ALK+ LBCL) is a rare neoplasm with an aggressive course and poor therapeutic response to the standard R-CHOP regimen. Owing to its negativity for usual B- and T-cell markers and immunopositivity for epithelial markers, it can be easily misdiagnosed if it is not contemplated. To study the clinicopathological parameters of cases of ALK+ LBCL diagnosed at our institution.
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