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Non-Invasive Nanometer Resolution Assessment of Cell-Soft Hydrogel System Mechanical Properties by Scanning Ion Conductance Microscopy.
Int J Mol Sci
December 2024
Department of Physics, M.V. Lomonosov Moscow State University, 1/2 Leninskie Gory, 119991 Moscow, Russia.
Biomimetic hydrogels have garnered increased interest due to their considerable potential for use in various fields, such as tissue engineering, 3D cell cultivation, and drug delivery. The primary challenge for applying hydrogels in tissue engineering is accurately evaluating their mechanical characteristics. In this context, we propose a method using scanning ion conductance microscopy (SICM) to determine the rigidity of living human breast cancer cells MCF-7 cells grown on a soft, self-assembled Fmoc-FF peptide hydrogel.
View Article and Find Full Text PDFCell-Penetrating Peptide Like Anti-Programmed Cell Death-Ligand 1 Peptide Conjugate-Based Self-Assembled Nanoparticles for Immunogenic Photodynamic Therapy.
ACS Nano
January 2025
BK21 Program, Department of Applied Life Science, Konkuk University, Chungju 27478, Republic of Korea.
The tumor-specific efficacy of the most current anticancer therapeutic agents, including antibody-drug conjugates (ADCs), oligonucleotides, and photosensitizers, is constrained by limitations such as poor cell penetration and low drug delivery. In this study, we addressed these challenges by developing, a positively charged, amphiphilic Chlorin e6 (Ce6)-conjugated, cell-penetrating anti-PD-L1 peptide nanomedicine (CPPD1) with enhanced cell and tissue permeability. The CPPD1 molecule, a bioconjugate of a hydrophobic photosensitizer and strongly positively charged programmed cell death-ligand 1 (PD-L1) binding cell-penetrating peptide (CPP), is capable of self-assembling into nanoparticles with an average size of 199 nm in aqueous solution without the need for any carriers.
View Article and Find Full Text PDFSelf-Assembly of Homo Phenylalanine Oligopeptides: Role of Oligopeptide Chain Length.
Langmuir
January 2025
Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
The self-assembly of phenylalanine (F)-based peptides is a critical area of research with potential implications for the development of advanced biomaterials and technologies. Previous studies indicate that homo-oligopeptides with F-X residues (X = 1 to 6) can self-assemble into diverse nano-microstructures, but the role of oligopeptide chain length on this process remains unclear. This review investigates the role of F-X chain length on self-assembly processes and morphologies, considering the effect of incubation conditions and the capping group at the N and/or C terminals.
View Article and Find Full Text PDFSelf-assembled peptide microtubes (SPMTs)/SnO sensors for enhanced room-temperature gas detection under visible light illumination.
Talanta
December 2024
Engineering Research Center of Smart Microsensors and Microsystems, Ministry of Education, College of Electronics and Information, Hangzhou Dianzi University, Hangzhou, Zhejiang, 310018, China; China-Israel Polypeptide Device and Application Technology Joint Research Center, Hangzhou, 310027, China. Electronic address:
Nitrogen dioxide (NO) is an important contaminant that poses a severe threat to environmental sustainability. Traditional inorganic NO gas detectors are generally used under harsh operating conditions and employ environmentally unfriendly resources, thus preventing widespread practical applications. Herein, self-assembled peptide microtubes (SPMTs) are combined with SnO nanoparticles (NPs) to develop a bioinspired NO gas sensor.
View Article and Find Full Text PDFInvestigation on the effects and mechanisms of novel peptide nanofiber gel to promote wound healing of deep second-degree burns in mice.
Int J Biol Macromol
December 2024
School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:
The self-assembled peptide RADA16-I (RADARADARADARADA) has been widely used in biomaterials. However, studies on the practical application of self-assembled peptide hydrogels loaded with bioactive peptides are still insufficient. In this study, we successfully prepared the peptide nanofiber gel RGJ by incorporating the bioactive peptides A8SGLP-1 (G) and Jagged-1 (J) into RADA16-I (R) in specific ratios.
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