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Role of continuous renal replacement therapy in management of the preliver transplant patient.
Curr Opin Organ Transplant
December 2024
Division of Nephrology, Department of Medicine, Indiana University School of Medicine.
Purpose Of Review: Highlight the importance of acute kidney injury (AKI) among liver transplant candidates, its importance of survival and the vital role of continuous renal replacement therapy (CRRT) as a supportive therapy.
Recent Findings: Kidney dysfunction is common in the preliver transplant patient. Early recognition, broad diagnostic work up, and therapeutic interventions are vital in minimizing morbidity and mortality in this critically ill group of patients.
The Global Kidney Patient Trials Network and the CAPTIVATE Platform Clinical Trial Design: A Trial Protocol.
JAMA Netw Open
December 2024
Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Importance: Chronic kidney disease (CKD) is a global health priority affecting almost 1 billion people. New therapeutic options and clinical trial innovations such as adaptive platform trials provide an opportunity to efficiently test combination therapies.
Objective: To describe the design and baseline results of the Global Kidney Patient Trials Network (GKPTN) and the design and structure of the global adaptive platform clinical trial Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE) to find new therapeutic options and treatments for people with kidney disease.
Combination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.
CNS Neurosci Ther
December 2024
Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background: Neurovascular coupling (NVC) reflects the close connection between neural activity and cerebral blood flow (CBF) responses, providing new insights to explore the neuropathological mechanisms of various diseases. Non-dialysis patients with chronic kidney disease (CKD) exhibit cognitive decline, but the underlying pathological mechanisms are unclear.
Methods: The prospective study involved 53 patients with stage 1-3a CKD (CKD1-3a), 78 patients with stage 3b-5 CKD (CKD3b-5), and 52 healthy controls (HC).
Five-year outcomes of a holistic programme for managing early chronic kidney disease in primary care.
Ann Acad Med Singap
October 2024
National University Polyclinics, National University Health System, Singapore.
Introduction: Holistic Approach in Lowering and Tracking Chronic Kidney Disease (HALT-CKD) is a nationwide programme that was introduced in 2017 to combat CKD in Singapore. This study aims to evaluate outcomes of the HALT-CKD programme and identify factors influencing disease progression among early CKD patients.
Method: We conducted a retrospective cohort study involving adult patients aged 21 to 80 with CKD stages G1-G3A, recruited from 5 Singapore polyclinics between 2017 and 2018.
Non-ST Elevation Myocardial Infarction in Patients With Hypertensive Emergency.
Cureus
July 2024
Department of Cardiology, Prakriya Hospitals, Nagasandra, IND.
Article Synopsis
- Hypertensive emergencies are severe blood pressure increases that pose high cardiovascular risks, with higher prevalence in NSTEMI patients compared to STEMI, and a notable increase in these emergencies among diabetic patients.
- The study involved 100 NSTEMI patients with hypertensive emergencies over 24 months, examining their coronary health and comparing diabetic to nondiabetic individuals through various tests and procedures.
- Findings indicated that diabetic patients often experienced more single-vessel diseases and had a slightly better ejection fraction than nondiabetic patients, highlighting key risk factors such as age, smoking, alcohol consumption, and medication nonadherence in developing hypertensive emergencies.
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