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I describe an assembly of neurons that synthesizes a chemorepellant molecule and transfers this molecule to the growth cones by axonal transport. From the growth cone, the repellant diffuses in nearby regions, achieving a certain concentration profile, delta, with a gradient. The growth cone migrates preferentially toward the regions of low delta. I show that this process self-consistently generates a profile of finite width, with a relatively sharp front of neuronal growth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829237 | PMC |
| http://dx.doi.org/10.1073/pnas.0609871104 | DOI Listing |
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