A galactose specific lectin was isolated from the seeds of Ficus bengalensis (Moraceae) fruits and designated as F. bengalensis agglutinin (FBA). The lectin was purified by affinity repulsion chromatography on fetuin-agarose and was a monomer of molecular mass 33kDa. Like other Moraceae family lectins, carbohydrate-binding activity of FBA was independent of any divalent cation. FBA did not bind with simple saccharides, however sugar ligands with aromatic aglycons showed pronounced binding. The combining site of FBA recognized preferably Galbeta1,4GlcNAcbeta1-(II) followed by Galbeta1,3GalNAcalpha1-(Talpha) containing glycotopes. Interaction with saccharides revealed that the combining site of FBA could well accommodate a tetrasaccharide, asialo GM1 glycan (Galbeta1,3GalNAcbeta1,4Galbeta1,4Glcbeta1-), whereas polyvalent Tn (GalNAcalpha1-Ser/Thr), one of the well-recognized ligands of Moraceae family lectin, did not interact well with FBA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carres.2007.02.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Moracin M promotes hair regeneration through activation of the WNT/β-catenin pathway and angiogenesis.
Arch Dermatol Res
January 2025
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 54538, South Korea.
Hair follicle growth depends on the intricate interaction of cells within the follicle and its vascular supply. Current FDA-approved treatments like minoxidil have limitations, including side effects and the need for continuous use. Moracin M, a compound from Moraceae family, was investigated for its effects on hair growth and vascular regeneration.
View Article and Find Full Text PDFFunctional leaf and plant use by leafcutter bees: Implications for management and conservation.
Ecol Appl
January 2025
Ecology labs, Department of Zoology, Central University of Kerala, Periya, Kerala, India.
Wild solitary bees face a host of challenges from the simplification of landscapes and biodiversity loss to invasive species and urbanization. Pollinator researchers and restoration workers thus far gave much attention to increase flower cover to reduce the impact of these anthropogenic pressures. Over 30% of bee species need nonfloral resources such as leaves and resin for their survival and reproduction.
View Article and Find Full Text PDFMorin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways.
Int Immunopharmacol
January 2025
Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
5-Fluorouracil (5-FU) is a DNA analog used in chemotherapy to treat various tumors. However, the clinical use of 5-FU is limited due to its severe adverse effects, particularly its nephrotoxicity. Morin (MRN) is a flavanol found in many different plants, including those in the Moraceae family, and has anti-inflammatory and antioxidant bioactivities.
View Article and Find Full Text PDFComprehensive nutritional, anti-nutritional, ICP-MS and FTIR profiling of leaves: a potential source for dietary enhancement.
Nat Prod Res
January 2025
Department of Chemistry, Gurukula Kangri (Deemed to be University), Haridwar, Uttarakhand, India.
is a plant belonging to the Moraceae family. This study aimed to profile the functional groups using FTIR, as well as nutritional, elements using ICP-MS technique, and anti-nutritional analyses of leaves. The results of nutritional analysis of leaves revealed that the leaves had a diverse proximate composition with derived nutritional value to be 314.
View Article and Find Full Text PDFLineage-specific patterns in the Moraceae family allow identification of convergent P450 enzymes involved in furanocoumarin biosynthesis.
New Phytol
January 2025
Université de Lorraine, INRAE, LAE, 54000, Nancy, France.
Specialized metabolites are molecules involved in plants' interaction with their environment. Elucidating their biosynthetic pathways is a challenging but rewarding task, leading to societal applications and ecological insights. Furanocoumarins emerged multiple times in Angiosperms, raising the question of how different enzymes evolved into catalyzing identical reactions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!