Objective: To investigate the diagnostic value of lumbar discography in discogenic low back pain and the effects of intervertebral fusion surgery.
Methods: Forty-five cases with 101 discs underwent discography, 360 degree fusion manipulation were performed on 18 discography abnormal cases, 27 cases were treated conservatively. Discography, MRI and provocative pain were observed and all the cases were followed up.
Results: Twenty-one cases showed positive provocative pain (21/45, 47%), and 21 discs of 101 were concordant discography (21/101, 21%). All cases were followed up for an average 16 months (15 to 23 months), the satisfactory rate was 83% (15/18) in the surgery group and 41% (11/27) in the conservative group.
Conclusions: It is concluded that the discography is moderately sensitive in the diagnosis of discogenic low back pain. Furthermore, the short term follow-up reveals that operative group has better pain relief than conservative group.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration.
JOR Spine
December 2024
Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin Dublin Ireland.
Article Synopsis
- Low back pain is mainly caused by degeneration of the intervertebral disc, prompting research into microRNA (miRNA) therapies which can modulate discogenic factors and inhibit degeneration.
- Nonviral cell penetrating peptides (CPPs) are favored for delivering these miRNAs due to their targeted delivery and low immune response.
- Results showed that dual miRNA delivery significantly enhanced discogenic marker expression and created a regenerative environment, indicating potential benefits for improved treatments for IVD repair.
Effectiveness of Intradiscal Regenerative Medicine Therapies for Long-Term Relief of Chronic Low Back Pain: A Systematic Review and Meta-Analysis.
Pain Physician
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: Recent research underscores the potential of intradiscal biologics, such as mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and alpha-2-macroglobulin, in promoting chondrogenesis within lumbar intervertebral discs as a treatment for discogenic low back pain. Studies indicate significant improvements in pain relief, physical function, and overall quality of life following these interventions.
Objective: This study aims to evaluate the effectiveness of intradiscal injections of MSCs and PRP in managing low back and lower extremity pain.
Thermal Annuloplasty for the Treatment of Discogenic Low Back Pain With a High-Intensity Zone After Full Endoscopic Discectomy.
Cureus
November 2024
Spinal Surgery, Kameda Medical Center, Chiba, JPN.
Discogenic low back pain (DLBP) is difficult to diagnose. We performed full endoscopic spinal surgery (FESS) with thermal annuloplasty for DLBP and achieved good results. Here, we report a case in which thermal annuloplasty resulted in good outcomes for refractory DLBP accompanied by a residual high-intensity zone (HIZ) after full endoscopic discectomy (FED).
View Article and Find Full Text PDFComment on "The Safety and Effectiveness of Orthobiologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up".
Pain Physician
November 2024
Department of Physical Medicine and Rehabilitation, Division of Pain Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Background: Preventing disc degeneration remains a clinical challenge; patients experiencing chronic lumbar discogenic pain have limited treatment options. Minimally invasive intradiscal procedures such as allogeneic nucleus pulposus (NP) injection have the potential to fill the treatment gap between failed conservative care and spine surgery.
Objectives: Our study sought to evaluate the magnitude and durability of improvement in back function in patients with chronic lumbar discogenic pain followed for 6 months after a single intradiscal injection of minimally manipulated, off-the-shelf processed NP allograft (VIA Disc NP®, VIVEX Biologics, Inc.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!