[The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma].

Objective: To study the expression of tumor necrosis factor related apoptosis induce ligand (TRAIL) receptors (DR4, DR5, DcR1, DcR2) in human laryngeal squamous cell carcinoma (LSCC).

Method: The expression and distribution of DR4, DR5, DcR1, DcR2 were detected by immunohistochemical method in 68 patients of LSCC and 40 laryngeal normal tissues (LNT).

Result: All of TRAIL receptors was observed in both tissues of LSCC and LNT. It was found that DR4, DR5 were overexpressed in the two tissues, indicating that there were no significant difference between the expressions of DR4 and DR5 in two tissues (P >0.05). DcR1 , DcR2 were over-expressed in LNT,were low expressed in LSCC (P <0. 05). Level of the TRAIL receptors DR5, DcR2 related with the degree of LSCC histological differentiation (P <0. 05). All receptors were not related with different clinical stage (P >0.05).

Conclusion: TRAIL receptors expression is generally expressed in human LSCC and LNT. The expression level of TRAIL receptors is various, which may explain the anti-cancer effect of TRAIL. The TRAIL receptor DcR1, DcR2 may play an important role in the apoptosis regulation of LSCC.