Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition.

Chem Commun (Camb)

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.

Published: March 2007

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd(3+) ions by coordination to the viral nucleoprotein show increased T(1) relaxivity relative to free Gd(DOTA) complexes in solution.

Download full-text PDF

Source
http://dx.doi.org/10.1039/b615084eDOI Listing

Publication Analysis

Top Keywords

azide-alkyne cycloaddition
8
viral mri
4
mri contrast
4
contrast agents
4
agents coordination
4
coordination native
4
native virions
4
virions attachment
4
attachment complexes
4
complexes azide-alkyne
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!