In this paper we propose a method for the nonrigid registration of contrast-enhanced dynamic sequences of magnetic resonance(MR) images. The algorithm has been developed with accuracy in mind, but also has a clinically viable execution time (i.e. a few minutes) as a goal. The algorithm is driven by multiresolution optical flow with the brightness consistency assumption relaxed, subject to a regularized best-fit within a family of transforms. The particular family of transforms we have employed uses a grid of control points and trilinear interpolation. We present validation results from a study simulating non-rigid deformation by a biomechanical model of the breast, with simulated uptake of a contrast agent. We further present results from applying the algorithm as part of a routine breast cancer screening protocol.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/11866763_84 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identity Model Transformation for boosting performance and efficiency in object detection network.
Neural Netw
December 2024
The State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, 129 Luoyu Road, Wuhan, 430079, China. Electronic address:
Modifying the structure of an existing network is a common method to further improve the performance of the network. However, modifying some layers in network often results in pre-trained weight mismatch, and fine-tune process is time-consuming and resource-inefficient. To address this issue, we propose a novel technique called Identity Model Transformation (IMT), which keep the output before and after transformation in an equal form by rigorous algebraic transformations.
View Article and Find Full Text PDFCO2 Reduction at a Borane-Modified Iron Complex: A Secondary Coordination Sphere Strategy.
Angew Chem Int Ed Engl
January 2025
Western University, Chemistry, 1151 Richmond Street, N6A3K7, London, CANADA.
This work addresses fundamental questions that deepen our understanding of secondary coordination sphere effects on carbon dioxide (CO2) reduction using derivatized hydride analogues of the type, [Cp*Fe(diphosphine)H] (Cp* = C5Me5-) - a well-studied family of organometallic complex - as models. More precisely, we describe the general reactivity of [(Cp*-BR2)Fe(diphosphine)H], which contains an intramolecularly positioned Lewis acid, and its cooperative reactivity with CO2. Control experiments underscore the critical nature of borane incorporation for CO2 to reduced products, a reaction that does not occur for unfunctionalized [Cp*Fe(diphosphine)H]).
View Article and Find Full Text PDFPRMT1-mediated BRD4 arginine methylation and phosphorylation promote partial epithelial-mesenchymal transformation and renal fibrosis.
FASEB J
January 2025
Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island, USA.
Bromodomain-containing protein 4 (BRD4) plays a vital role in fibrosis of various organs. However, the underlying mechanism of BRD4 in renal fibrosis remains unclear. To construct in vitro and in vivo models of renal fibrosis, TCMK-1 cells were subjected to TGF-β1 treatment and mice were subjected to UUO surgery and adenine induction.
View Article and Find Full Text PDFOutsiders at Medical School: Indigenous experiences in medical courses at Brazilian federal universities.
Cien Saude Colet
December 2024
Departamento de Saúde Pública, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista. São Paulo SP Brasil.
In recent decades, affirmative actions have enabled Indigenous people to access medical school, historically occupied by white people with high family incomes. This research analyzed experiences of otherness by Indigenous people in federal medical schools. This qualitative, exploratory study adopted interviews and conversation circles, with the participation of 40 students from 15 courses.
View Article and Find Full Text PDFTargeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in -familial platelet disorder.
Sci Transl Med
January 2025
Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Familial platelet disorder (FPD) is associated with germline mutations, establishing a preleukemic state and increasing the risk of developing leukemia. Currently, there are no intervention strategies to prevent leukemia progression. Single-cell RNA sequencing ( = 10) combined with functional analysis of samples from patients with -FPD ( > 75) revealed that FPD hematopoietic stem and progenitor cells (HSPCs) displayed increased myeloid differentiation and suppressed megakaryopoiesis because of increased activation of prosurvival and inflammatory pathways.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!