Three new prenylated anthranoids, harunmadagascarins C (1) and D (2) and kenganthranol D (3), together with three known compounds (4-6) were isolated from the leaves of Harungana madagascariensis. Their structures were assigned by spectroscopic methods and by comparison with literature data. In the three new natural products 1-3, one or two prenyl groups are incorporated in furan, pyran, or cyclohexane rings in four different modes of annulation. Compounds 2, 4, and 6 were strongly active against the Gram-positive Bacillus megaterium.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np060556l | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Handling the heat - photosynthetic thermal stress in tropical trees.
New Phytol
January 2022
Department of Biological and Environmental Sciences, University of Gothenburg, PO Box 461, Gothenburg, SE-405 30, Sweden.
Warming climate increases the risk for harmful leaf temperatures in terrestrial plants, causing heat stress and loss of productivity. The heat sensitivity may be particularly high in equatorial tropical tree species adapted to a thermally stable climate. Thermal thresholds of the photosynthetic system of sun-exposed leaves were investigated in three tropical montane tree species native to Rwanda with different growth and water use strategies (Harungana montana, Syzygium guineense and Entandrophragma exselsum).
View Article and Find Full Text PDFPharmacological Assessment of the Antiprotozoal Activity, Cytotoxicity and Genotoxicity of Medicinal Plants Used in the Treatment of Malaria in the Greater Mpigi Region in Uganda.
Front Pharmacol
June 2021
Department of Agriculture and Food Sciences, Neubrandenburg University of Applied Sciences, Neubrandenburg, Germany.
We investigated the potential antimalarial and toxicological effects of 16 medicinal plants frequently used by traditional healers to treat malaria, fever, and related disorders in the Greater Mpigi region in Uganda. Species studied were , , , , , , , , , , , , , , and . In addition, the traditional healers indicated that is used as a ritual plant to boost fertility and prepare young women and teenagers for motherhood in some Ugandan communities where a high incidence of rapidly growing large breast masses in young female patients was observed (not necessarily breast cancer).
View Article and Find Full Text PDFLimited thermal acclimation of photosynthesis in tropical montane tree species.
Glob Chang Biol
October 2021
Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden.
The temperature sensitivity of physiological processes and growth of tropical trees remains a key uncertainty in predicting how tropical forests will adjust to future climates. In particular, our knowledge regarding warming responses of photosynthesis, and its underlying biochemical mechanisms, is very limited. We grew seedlings of two tropical montane rainforest tree species, the early-successional species Harungana montana and the late-successional species Syzygium guineense, at three different sites along an elevation gradient, differing by 6.
View Article and Find Full Text PDFParts, Period, and Extraction Solvents as Parameters Influencing Lam. ex Poir. (Hypericaceae) Antibacterial Activity.
Evid Based Complement Alternat Med
March 2021
Laboratory of Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Douala, P.O. Box 24157, Douala, Cameroon.
The study of the conditions which affect the pharmacological activity of medicinal plants is the basis for the development of phytomedicine. This study aimed at identifying some optimal conditions for antibacterial activity of extracts of . The leaves, bark, and roots were harvested in Douala, Littoral Region of Cameroon, in August 2019 at three times of the day: early in the morning (6 a.
View Article and Find Full Text PDFTargeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda.
Sci Rep
July 2020
Department of Dermatology, Emory University School of Medicine, 615 Michael St., Atlanta, GA, 30322, USA.
Antibiotic resistance poses one of the greatest threats to global health today; conventional drug therapies are becoming increasingly inefficacious and limited. We identified 16 medicinal plant species used by traditional healers for the treatment of infectious and inflammatory diseases in the Greater Mpigi region of Uganda. Extracts were evaluated for their ability to inhibit growth of clinical isolates of multidrug-resistant ESKAPE pathogens.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!