AI Article Synopsis
- The study explores the connection between T-cell responses to mycobacterial antigens and the risk of developing tuberculosis disease.
- A 55-year-old man showed a significant increase in ELISPOT count, indicating T-cell activity, before symptoms of the disease appeared.
- This case suggests that monitoring ELISPOT count changes could help predict when someone with M. tuberculosis infection might progress to actual disease.
Article Abstract
The relationship between the T-cell response to mycobacterial antigens and the likelihood of progression to disease has not been defined. We report a rapidly rising ELISPOT count in a 55-year-old man with evidence of Mycobacterium tuberculosis infection prior to the onset of symptoms of disease. This case illustrates the possible utility of quantitative changes in the ELISPOT count in predicting progression from M. tuberculosis infection to disease.
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