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Primary pulmonary epithelioid hemangioendothelioma metastatic to the pleura and mediastinal lymph node with a prominent rhabdoid cytomorphology showing CAMTA1::WWTR1 fusion and novel PRDM1 and TNFRSF14 mutations.
Cytopathology
September 2024
Department of Pathology-Genomic Cancer Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Cases of epithelioid hemangioendothelioma with WWTR1::CAMTA1 fusion can show rhabdoid cytomorphology. Lack of intracytoplasmic luminal spaces, marked rhabdoid cytomorphology, and variability in the expression of vascular markers makes the diagnosis of EHE challenging. Therefore, a high level of suspicion and ancillary studies (immunohistochemistry and next generation sequencing) help reach a definitive diagnosis in these cases.
View Article and Find Full Text PDFPrimary Epithelioid Angiosarcoma of the Submandibular Gland-A Case Report with Histology-Cytology Correlation and Comprehensive Molecular Analysis.
Head Neck Pathol
June 2024
Department of Pathology, National University Hospital, Singapore, Singapore.
Article Synopsis
- * A case study on a 73-year-old man revealed a tumor initially thought to be a poorly differentiated carcinoma, but subsequent examination confirmed it as epithelioid angiosarcoma, with specific molecular characteristics identified through advanced testing methods.
- * The findings highlight the need to consider epithelioid angiosarcoma as a differential diagnosis for high-grade salivary gland carcinomas, noting the potential for shared genetic alterations like TP53 mutations that complicate diagnosis.
L1 Cell Adhesion Molecule (L1CAM) Expression and Molecular Alterations Distinguish Low-Grade Oncocytic Tumor From Eosinophilic Chromophobe Renal Cell Carcinoma.
Mod Pathol
May 2024
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
Renal low-grade oncocytic tumor (LOT) is a recently recognized renal cell neoplasm designated within the "other oncocytic tumors" category in the 2022 World Health Organization classification system. Although the clinicopathologic, immunohistochemical, and molecular features reported for LOT have been largely consistent, the data are relatively limited. The morphologic overlap between LOT and other low-grade oncocytic neoplasms, particularly eosinophilic chromophobe renal cell carcinoma (E-chRCC), remains a controversial area in renal tumor classification.
View Article and Find Full Text PDFPapillary Thyroid Carcinoma with Intracytoplasmic Lumina: A Diagnostic Pitfall on Aspiration Cytology of a Metastatic Site.
J Cytol
August 2023
Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.
Extremely intricate labyrinthine structures: an electron microscopic observation of peculiar invaginations of the plasma membrane found in secretory meningioma.
Int J Clin Exp Pathol
August 2022
Department of Pathology, Hikone Municipal Hospital 1882 Hassaka, Hikone, Shiga 522-8539, Japan.
Large, extremely intricate labyrinthine structures were observed during an electron microscopic examination of a secretory meningioma that originated in the sphenoid ridge of a 73-year-old man. In many neoplastic cells, these labyrinthine structures formed round-shaped regions within the cytoplasm, and profiles indicated their internal structure consisted of numerous thin fragments of cytoplasm and intervening flocculent material. These labyrinthine structures did not exhibit apparent topographic association with pseudopsammoma bodies, and direct communication with the extracellular space by very thin channels was rarely observed.
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