AI Article Synopsis
- The discovery of the genetic code significantly advanced biology, revealing that DNA does more than just code for proteins.
- DNA includes additional signals for processes like splicing, localization, and regulation—all found within the protein-coding regions.
- Itzkovitz and Alon argue that the specific mapping in the genetic code may have evolved to optimize the carrying of this extra information while also reducing negative impacts from errors in reading the genetic code.
Article Abstract
The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.
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| http://dx.doi.org/10.1101/gr.6144007 | DOI Listing |
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