Computerized perimetry analysis of the visual field enables the capacity of the visual cortex to process the electric impulse received from the eyeball to be detected. Considering that hypercholesterolemia can cause cognitive worsening by altering the functioning of the cerebral cortex, we attempted to determine whether it can affect the cortical processing of the visual stimuli, as detected by computerized perimetry. We undertook computerized perimetry analysis of 208 male and female patients (mean age, 48.5 years) with plasma low density lipoprotein (LDL) cholesterol concentrations above 3.36 mmol/L and compared the results with the same number of matched controls with LDL cholesterol concentrations below 3.36 mmol/L. No subject had any neuro-ophthalmological disease that could have affected the results. A Humphrey 745 computerized perimetry device was used to measure the mean deviation, the pattern standard deviation, the corrected pattern standard deviation, short-term fluctuations and the foveal threshold. Compared with the control subjects, the patients with hypercholesterolemia showed worsening in all the perimetry variables analyzed. Moreover, we also found a direct association between plasma LDL cholesterol concentrations and the perimetry alterations, and an inverse association between these alterations and the figures for HDL cholesterol. Our data show that computerized perimetry can detect alterations in the visual field of persons with hypercholesterolemia, suggesting that increased plasma concentrations of cholesterol may have a negative influence on the visual neuron cells.
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http://dx.doi.org/10.1016/j.atherosclerosis.2007.01.013 | DOI Listing |
Psychoneuroendocrinology
December 2024
Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:
Appetite hormones may play a significant role in neuronal excitability and synaptic plasticity and may also affect brain function development. This study aimed to explore the role of appetite hormones in attention deficit/hyperactivity disorder (ADHD), including aspects of pathophysiology, pharmacotherapy, and side effects. We recruited 119 patients with ADHD who were undergoing methylphenidate treatment (ADHD+MPH), 77 unmedicated ADHD patients (ADHD-MPH), and 87 healthy controls.
View Article and Find Full Text PDFClin Exp Ophthalmol
November 2024
School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
J Clin Med
May 2024
Department of Biophysics, Medical University of Lublin, K. Jaczewskiego 4, 20-090 Lublin, Poland.
: The aim of the study was to demonstrate the influence of virtual reality (VR) exposure on postural stability and determine the mechanism of this influence. : Twenty-six male participants aged 21-23 years were included, who underwent postural stability assessment twice before and after a few minute of single VR exposure. The VR projection was a computer-generated simulation of the surrounding scenery.
View Article and Find Full Text PDFClin Exp Optom
April 2024
Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Clinical Relevance: Accurate colour vision assessment is important in clinical settings to minimise false-positive errors and enhance the reliability of diagnoses outcomes.
Background: Colour vision testing is valuable in assessing the visual system, particularly given the high proportion of individuals with poor vision. This study aimed to determine the minimum visual acuity level required to perform a colour-vision test without errors.
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