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Primary perineuritis, a rare but treatable neuropathy: Review of perineurial anatomy, clinicopathological features, and differential diagnosis.
Muscle Nerve
November 2023
Neuromuscular Pathology Laboratory, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Article Synopsis
- The perineurium is a protective layer surrounding nerve fascicles, crucial for maintaining the blood-nerve barrier; its inflammation can lead to a condition known as primary perineuritis (PP).
- PP is often misdiagnosed as nonsystemic vasculitic neuropathy until confirmed through nerve biopsy, which shows T-cell inflammation and specific changes in nerve structure.
- Despite the challenges in diagnosis, most patients respond well to corticosteroids and immunomodulators, with a variety of underlying causes for perineuritis noted, including infections and autoimmune diseases.
Abrupt Onset of Cardiac Tamponade in Sarcoidosis.
Int Heart J
September 2021
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.
Sarcoidosis is a systemic inflammatory disease characterized by the formation of noncaseating epithelioid granulomas. Multiple organs, including the lung, eyes, and skin, are involved in this disorder, and cardiac involvement is a major cause of morbidity and mortality in patients with this disorder. We present the case history of a 22-year-old man with neurosarcoidosis complicated by abrupt onset of cardiac tamponade.
View Article and Find Full Text PDFImmune-Mediated Disorders Affecting the Spinal Cord and the Spine.
Curr Neurol Neurosci Rep
January 2021
Department of Neurology, The University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd. Suite 2547, Oklahoma City, OK, 73104, USA.
Purpose Of Review: To review the most recent advances and provide a description of the most common autoimmune diseases causing myelitis and selective spine disorders. The ultimate goal of this article is to facilitate the prompt recognition of these diseases.
Recent Findings: The recent discovery of biomarkers such as aquaporin 4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies has changed our understanding of autoimmune diseases affecting the spinal cord as well as their treatment and outcomes.
Frequency and etiology of acute transverse myelitis in Southern Finland.
Mult Scler Relat Disord
November 2020
Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland. Electronic address:
Objective: Acute transverse myelitis is a relatively rare, frequently debilitating but potentially treatable emergency. The objective of this study was to evaluate the incidence and etiology of acute transverse myelitis in two major hospital districts in Southern Finland.
Methods: We identified all patients with acute transverse myelitis admitted to Turku University Hospital and Päijät-Häme Central hospital during nine years.
[A man in his sixties with gait ataxia, dysarthria and mild cognitive impairment].
Tidsskr Nor Laegeforen
March 2020
Background: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is an immune-mediated, treatable and inflammatory CNS disease first reported by Pittock et al. (2010).
Case Presentation: We describe a 66-year-old man with previous history of diabetes, atrial fibrillation and hypertension, who was admitted to hospital with reduced general condition.
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