Diplopia and diarrhea: ileal carcinoid metastatic to the central nervous system.

Am J Gastroenterol

Division of Digestive Diseases, Jackson Veterans Affairs Medical Center, Mississippi.

Published: February 1992

The case of a patient with metastatic ileal carcinoid is reported. The peculiarities of this case were as follows: 1) The patient presented with symptoms attributable to a mass lesion in the brain which was proven to be a carcinoid tumor by biopsy. 2) The patient had symptoms attributable to carcinoid syndrome without radiologic evidence of hepatic metastasis. 3) No bony or pulmonary metastasis was evident, which suggests that the metastatic spread from the ileum occurred through the spinous venous plexus of Batson. The patient's symptoms were managed with cyproheptadine with good effect. A review of the carcinoid syndrome and the determinants of its metastatic spread is presented.

Download full-text PDF

Source

Publication Analysis

Top Keywords

ileal carcinoid
8
case patient
8
symptoms attributable
8
carcinoid syndrome
8
metastatic spread
8
carcinoid
5
diplopia diarrhea
4
diarrhea ileal
4
metastatic
4
carcinoid metastatic
4

Similar Publications

Colonic neuroendocrine tumors (NETs), excluding rectal NETs, are often described as relatively common and aggressive, with inferior median survival compared with other gastrointestinal (GI) primary sites. However, epidemiological databases may conflate well-differentiated NETs with poorly differentiated neuroendocrine carcinomas (NECs), leading to a lack of precise data on the prevalence, clinical behavior, and prognosis of well-differentiated colonic NETs. We analyzed a large institutional database to identify patients with well-differentiated NETs originating in the colon, excluding rectal NETs.

View Article and Find Full Text PDF

Objective: The aim of this study was to evaluate the performance of different biomarkers for the detection of carcinoid heart disease (CHD) in neuroendocrine tumours (NETs), in particular serum 5-HIAA (s5HIAA).

Design: An explorative ancillary study of the French CrusoeNET cohort.

Methods: Patients managed in the Lyon-EURACAN Center of Excellence (CoE) were included when they were aged of at least 18 years, treated and followed for an advanced/metastatic ileum or lung NET, a NET irrespective of the primary location or from unknown primary location but with clinical CS, and/or elevation of urinary 5-HIAA (u5HIAA) twice greater than the upper limit of normal.

View Article and Find Full Text PDF
Article Synopsis
  • A case is presented involving a NET in the ileal pouch of a UC patient with primary sclerosing cholangitis who had undergone surgery and liver transplantation.
  • The article includes a review of existing literature on this topic, highlighting the limited reports on NET occurrence in ileal pouches in UC patients.
View Article and Find Full Text PDF

Efficacy of Racecadotril in a Patient Affected by a Therapy-Refractory VIPoma and Carcinoid Syndrome.

JCEM Case Rep

October 2024

Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.

Article Synopsis
  • - Neuroendocrine neoplasms (NENs) are diverse tumors from neuroendocrine cells, with about 30% causing hormone-related syndromes that can significantly impact patient health beyond the tumor size itself.
  • - A 49-year-old male patient with an ileal NEN exhibited concurrent VIP and serotonin release, leading to a severe diarrhea syndrome after receiving peptide-radio-receptor therapy, despite ongoing medical treatments.
  • - As traditional treatment options were no longer effective, an off-label use of racecadotril helped manage the patient's condition, allowing him to leave the ICU after five days of treatment.
View Article and Find Full Text PDF

Late perforation of the ileum is a rare and potentially life-threatening complication following intestinal resection. We present a unique case of a woman in her 60s with a history of appendiceal carcinoid tumour, who underwent a right hemicolectomy. Positron emission tomography and surveillance CTs showed normal surgical changes and no recurrent malignancy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!