Several classes of compounds (thioureas, ureas, beta-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.
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| http://dx.doi.org/10.2174/138955707780059880 | DOI Listing |
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