Fresh parsley leaves and roots were analyzed by HPLC and photobiological assay for photoactive furocoumarins. Oxypeucedanin ( 7), not previously reported from parsley, was found to be the major component (70-100 ppm wet weight). Although only moderately photoactive, its high concentration in parsley may be partially responsible for contact photodermatitis. Other photoactive compounds, namely 5-MOP ( 2), 8-MOP ( 3), psoralen ( 1), isopimpinellin ( 4) and imperatorin ( 5) were also present and quantified.
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http://dx.doi.org/10.1055/s-2007-969254 | DOI Listing |
J Ethnopharmacol
February 2022
Department of Pharmaceutical Botany, Faculty of Pharmacy, Ege University, Izmir, Turkey. Electronic address:
Ethnopharmacological Relevance: Erectile dysfunction (ED) is the most common form of sexual dysfunction which has been the topic of great interest through the history by all cultures. It is now among the most treated health problems in men of all ages that develop under the influence of lifestyle factors and some diseases. Plants are extensively used to cure sexual dysfunction for centuries.
View Article and Find Full Text PDFCurr Drug Metab
March 2022
Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Background: Herbal medicine Angelica dahurica is widely employed for the treatment of rheumatism and pain relief in China. Oxypeucedanin is a major component in the herb.
Objectives: The objectives of this study are aimed at the investigation of mechanism-based inactivation of CYP2B6 and CYP2D6 by oxypeucedanin, characterization of the reactive metabolites associated with the enzyme inactivation, and identification of the P450s participating in the bioactivation of oxypeucedanin.
ACS Omega
December 2020
Metalloenzyme Research Group and Department of Plant Science and Technology, Chung-Ang University, 4726 Seodong-daero, Anseong 17546, Republic of Korea.
Gut metabolism of natural products is of great interest due to the altered biological activity of the metabolites. To study the gut metabolism of the dietary furanocoumarins, the biotransformation of was studied with human gut microbiota. The major components of , including xanthotoxin (), bergapten (), imperatorin (), isoimperatorin (), oxypeucedanin (), and byakangelicol (), were all metabolized by the human fecal sample, and each furanocoumarin was also biotransformed by sp.
View Article and Find Full Text PDFHeliyon
June 2019
Universidad Nacional de Colombia-Sede Medellín. Facultad de Ciencias, Escuela de Química, Carrera 65 No. 59a-110, Medellín, Colombia.
The present work analyses the chromatographic profile of the peels from fruits of different citrus cultivated in Colombia: sweet orange ( [L.] Osbeck var. Valencia), mandarins ( L.
View Article and Find Full Text PDFJ Ethnopharmacol
February 2018
State Key Laboratory of Toxicology and Medical Countermeasures, 100850 Beijing, China; Beijing Institute of Pharmacology and Toxicology, 100850 Beijing, China. Electronic address:
Ethnopharmacological Relevance: Radix Angelica dahuricae (RAD), the roots of Angelica dahurica (Hoffm.) Benth. & Hook.
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