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Physical injury in men after sexual assault: An analysis of 137 cases.
Forensic Sci Int
December 2024
Department of Obstetrics & Gynaecology, Royal College of Surgeons in Ireland, Rotunda Hospital, Parnell Square, Dublin 1, Ireland; Sexual Assault Treatment Unit, Rotunda Hospital, Dublin 1, Ireland.
Background: Data on the prevalence of physical injury in men who experience sexual assault are under-represented in the literature; the aim of this study is to inform this knowledge gap. It is vital that forensic examiners have access to up-to-date information regarding the prevalence of genito-anal and extra-genital injury, specific to their examination method (i.e.
View Article and Find Full Text PDFCarboplatin and Paclitaxel Chemoradiation for Localized Anal Cancer in Patients Not Eligible for Mitomycin and 5-Fluorouracil.
Cancers (Basel)
September 2024
Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.
Article Synopsis
- Squamous cell carcinoma of the anus (SCCA) is becoming more common in the U.S., and while standard treatments have high toxicity, carboplatin and paclitaxel (C/P) combined with radiation may offer a safer alternative for patients who can't tolerate standard chemoradiation.
- In a study with ten patients (average age 75.5), 89% achieved a complete clinical response, and 67% remained alive without recurrence after a median follow-up of about 26 months.
- Common toxicities included leukopenia, anemia, and diarrhea, with severe side effects affecting a notable percentage, but overall, the C/P regimen showed good tolerability and effectiveness.
Predictive value of flexible proctosigmoidoscopy and laboratory findings for complete clinical responses after neoadjuvant chemoradiotherapy in patients with locally advanced primary rectal cancer: a retrospective cohort study.
Int J Colorectal Dis
August 2024
Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: Colorectal cancer is the second leading cause of cancer death worldwide. Standard treatments for locally advanced rectal cancer include neoadjuvant chemoradiotherapy and total mesorectal excision (TME), which are associated with significant morbidity. After neoadjuvant therapy, one-third of patients achieve a pathological complete response (pCR) and are eligible for a watch-and-wait approach without TME.
View Article and Find Full Text PDFWatch and wait in rectal cancer patients with residual mucin on magnetic resonance imaging following neoadjuvant therapy.
J Natl Cancer Inst
November 2024
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Neoadjuvant therapy leads to a clinical complete response in a considerable proportion of patients with locally advanced rectal cancer, allowing for possible nonoperative management. The presence of mucin on magnetic resonance imaging (MRI) after neoadjuvant therapy leads to uncertainty about residual disease and appropriateness of a watch-and-wait strategy in patients with no evidence of disease on proctoscopy (endoscopic clinical complete response).
Methods: MRI reports for locally advanced rectal cancer patients seen between July 2016 and January 2020 at Memorial Sloan Kettering Cancer Center were queried for presence of mucin in the tumor bed on MRI following neoadjuvant therapy.
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