AI Article Synopsis
- The study aimed to investigate how variations in the GTP cyclohydrolase gene (GCH1) affect pain sensitivity in humans.
- Methodology included testing thermal and cold pain sensitivity in 735 healthy volunteers and analyzing genetic variations in 221 subjects after wisdom tooth surgery.
- Results showed significant differences in allele frequencies among different ethnic groups, but the expected strong influence of GCH1 variations on pain sensitivity was not confirmed in European Americans, suggesting previous associations might be weak or negligible.
Article Abstract
Objectives: To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans.
Methods: Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers. Among this cohort, the clinical pain responses of 221 subjects after the surgical removal of impacted third molars were evaluated. Genotyping was done for 38 single nucleotide polymorphisms (SNPs) whose heterozygosity > 0.2 in GCH1. Influence of the genetic variations including SNPs and haplotypes on pain sensitivity were analyzed.
Results: Minor allele frequencies and linkage disequilibrium show significant differences in European Americans, African Americans, Hispanic Americans and Asian Americans. Association analyses in European Americans do not replicate the previously reported important influence of GCH1 variations on pain sensitivity.
Conclusion: Considering population stratification, previously reported associations between GCH1 genetic variations and pain sensitivity appear weak or negligible in this well characterized model of pain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821314 | PMC |
| http://dx.doi.org/10.1186/1744-8069-3-6 | DOI Listing |
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