A right-handed Japanese man with no personal or family history of left-handedness developed severe Wernicke's aphasia, a mild constructional disorder, and slight left hemiparesis. MRI revealed infarction in the territory of the righ middle cerebral artery, including areas homologous to Broca's and Wernicke's areas. The cerebral blood flow in these areas remained diminished even after language activation. The most likely explanation is that language production occurred in the left Broca's area, while language comprehension occurred in the right Wernicke's area (a dissociated aphasia).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1212/wnl.42.1.144 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital tool as speech and language therapy for patients with post-stroke aphasia.
Digit Health
January 2025
Department of Neurology and Stroke Centre, Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Autonomous University of Madrid), Madrid, Spain.
Introduction: New technologies could play a role in post-stroke aphasia (PSA). Our aims were to develop a digital tool; to evaluate its acceptance and usability by patients and caregivers; and to demonstrate its effectiveness in improving language skills in patients with PSA, applying it from the acute phase.
Methods: The study consisted of two phases: development of a digital tool; and an interventional before-and-after study.
Cerebrovascular thrombosis is among the most critical medical conditions, making early diagnosis and management crucial. Although some symptoms of cerebrovascular thrombosis are typical and lead to early diagnosis, they can sometimes present with rare and unusual symptoms, complicating the diagnostic process. Given the morbidity and mortality associated with these events, it is important to be aware of unexpected symptoms to diagnose and manage these patients more accurately and rapidly.
View Article and Find Full Text PDFImpaired semantic control in the logopenic variant of primary progressive aphasia.
Brain Commun
December 2024
Medical Research Council (MRC) Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, UK.
We investigated semantic cognition in the logopenic variant of primary progressive aphasia, including (i) the status of verbal and non-verbal semantic performance; and (ii) whether the semantic deficit reflects impaired semantic control. Our hypothesis that individuals with logopenic variant of primary progressive aphasia would exhibit semantic control impairments was motivated by the anatomical overlap between the temporoparietal atrophy typically associated with logopenic variant of primary progressive aphasia and lesions associated with post-stroke semantic aphasia and Wernicke's aphasia, which cause heteromodal semantic control impairments. We addressed the presence, type (semantic representation and semantic control; verbal and non-verbal), and progression of semantic deficits in logopenic variant of primary progressive aphasia.
View Article and Find Full Text PDFAn atypical presentation of Wernicke-Korsakoff encephalopathy mimicking a left hemispheric stroke: case report.
Front Psychiatry
December 2024
Department of Neurology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Article Synopsis
- Wernicke-Korsakoff encephalopathy, a condition caused by vitamin B1 deficiency, often affects alcoholics and is characterized by memory issues, eye movement problems, and coordination difficulties.
- A young male patient with a history of alcohol abuse presented with symptoms resembling a stroke, including right-sided weakness and language disturbances, complicating accurate diagnosis.
- Following treatment with intravenous vitamin B1, the patient ultimately made a full recovery, highlighting how this condition can mimic stroke symptoms and posing challenges in emergency medical settings.
Primary Progressive Aphasia Lacking Core Features of Nonfluent and Semantic Variants: Clinical, Neuroimaging, and Neuropathologic Features.
Neurology
November 2024
From the Departments of Neurology (H.W., J.R.D., H.C., J.G.-R., K.A.J.), Psychology (M.M.M.), and Radiology (N.T.T.P., V.J.L., J.L.W.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (Neuropathology) (D.W.D.), Mayo Clinic, Jacksonville, FL.
Article Synopsis
- This study investigates the limitations of the 2011 consensus criteria for primary progressive aphasia (PPA), specifically focusing on features of logopenic variant PPA and aiming to refine the classification system based on clinical and neuroimaging data.
- A retrospective analysis of 102 PPA patients revealed a predominance of repetition-preserved variants over repetition-impaired ones, suggesting different clinical courses and potential prodromal stages among the subgroups identified (pure-LPA, Wernicke-like, anomic-like, and TCSA-like).
- Neuroimaging showed consistent left temporoparietal atrophy across groups, with severe hypometabolism linked to repetition deficits, while pathologically, 70% of patients had Alzheimer's disease, with varying
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!