AI Article Synopsis
- Inducing CYP7A1 in the liver could help prevent high cholesterol and atherosclerosis.
- Researchers tested dipeptides with a lysine group on HepG2 cells to see their effects on CYP7A1 mRNA levels.
- The dipeptides Asp-Lys, Glu-Lys, and Trp-Lys were found to significantly boost CYP7A1 mRNA expression.
Article Abstract
Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7alpha-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.
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| http://dx.doi.org/10.1271/bbb.60639 | DOI Listing |
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