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Delays in Diagnostic Colonoscopy After Positive FIT in an Integrated Healthcare System.
Dig Dis Sci
January 2025
Division of Hospital and Specialty Medicine, Portland VA Medical Center, Portland, USA.
Background: Colorectal cancer screening with fecal immunochemical testing (FIT) is a process that depends on diagnostic colonoscopy for those with a positive test and completion of colonoscopy after positive FIT is an essential element of program effectiveness.
Aims: We examined how the COVID-19 pandemic influenced completion of diagnostic colonoscopy after positive FIT in our integrated healthcare system.
Methods: This was a retrospective study of all positive FIT over a 5-year period.
Objective: The effectiveness of behavioral interventions is typically evaluated relative to control conditions using null hypothesis significance testing (i.e., < .
View Article and Find Full Text PDFComparison of Conjugates Obtained Using DMSO and DMF as Solvents in the Production of Polyclonal Antibodies and ELISA Development: A Case Study on Bisphenol A.
Antibodies (Basel)
October 2024
A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia.
When developing immunochemical test systems, it is necessary to obtain specific antibodies. Their quality depends, among other things, on the immunogen used. When preparing hapten-protein conjugates to obtain antibodies for low-molecular-weight compounds, the key factors are the structure of the hapten itself, the presence of a spacer, the size of the carrier protein and the degree of its modification by hapten molecules.
View Article and Find Full Text PDFFIT as a Comparator for Evaluating the Effectiveness of New Non-invasive CRC Screening Test.
Dig Dis Sci
November 2024
CHU Caen Normandie, INSERM ANTICIPE U1086, Université Caen Normandie, 14000, Caen, France.
Randomized Controlled Trials (RCT) demonstrated that guaiac-based fecal occult blood test (gFOBT), sigmoidoscopy, or colonoscopy are effective at reducing colorectal cancer (CRC) risk and mortality. Even if the impact of fecal immunochemical test (FIT) has not been evaluated within population-based RCT with mortality as the outcome, the results of comparative analyses with gFOBT provide strong indirect evidence of its effectiveness. Extensive information is also available on sensitivity and specificity of FIT, compared with gFOBT.
View Article and Find Full Text PDFNot just a Barbie in hijab: participant perspectives on culturally tailoring a virtual health assistant for Bangladeshi immigrants in the US promoting colorectal cancer screening.
Mhealth
October 2024
Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
Background: Colorectal cancer (CRC) screening uptake among South Asian immigrants in the US is the lowest (61.1%) of all immigrant groups (e.g.
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