Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cmdc.200600206 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Revealing NOD1-Activating Gram-Positive Gut Microbiota via in Vivo Labeling with a meso-Diaminopimelic Acid Probe.
ACS Chem Biol
January 2025
Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
As an important receptor in a host's immune and metabolic systems, NOD1 is usually activated by Gram-negative bacteria having -diaminopimelic acid (-DAP) in their peptidoglycan (PGN). But some atypical Gram-positive bacteria also contain -DAP in their PGN, giving them the potential to activate NOD1. The prevalence of -DAP-type Gram-positive bacteria in the gut, however, remains largely unknown.
View Article and Find Full Text PDFEffects of water and sediment chemistry variables on aquatic macroinvertebrate community structuring in a subtropical Austral river system.
Environ Sci Pollut Res Int
January 2025
South African Institute for Aquatic Biodiversity, Makhanda, 6140, South Africa.
Riverine physical and chemical characteristics are influencing ecosystem integrity while shaping and impacting species richness and diversity. Changes in these factors could potentially influence community structuring through competition, predation and localised species extinctions. In this study, eight sampling sites over multiple seasons were assessed along the streams draining the City of Nelspruit, South Africa, to examine river health based on water and sediment quality, while using macroinvertebrates as bioindicators for pollution.
View Article and Find Full Text PDFDiscovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
J Med Chem
January 2025
Department of Neurology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
The death signaling complex comprising extrasynaptic NMDAR and TRPM4 plays a pivotal role in the pathogenesis of ischemic stroke. Targeting the protein-protein interactions between NMDAR and TRPM4 represents a promising therapeutic strategy for ischemic stroke. Herein, we describe the discovery of a novel series of NMDAR/TRPM4 interaction interface inhibitors aimed at enhancing neuroprotective efficacy and optimizing pharmacokinetic profiles.
View Article and Find Full Text PDFFAIR data - the photon and neutron communities move together towards open science.
IUCrJ
January 2025
Department of Physics, University of Siegen, Siegen, Germany.
The topic of data storage, traceability, and data use and reuse in the years following experiments is becoming an important topic in Europe and across the world. Many scientific communities are striving to create open data by the FAIR principles. This is a requirement from the European Commission for EU-funded projects and experiments at EU-funded research infrastructures (RIs) and from many national funding agencies.
View Article and Find Full Text PDFNADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1.
ACS Sens
January 2025
Hubei Key Laboratory of Genetic Regulation & Integrative Biology, Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Life Sciences, Central China Normal University, Wuhan 430079, China.
Heme oxygenase-1 (HO-1) catalyzes heme degradation on the consumption of NADPH and molecular oxygen. As an inducible enzyme, HO-1 is highly induced in various disease states, including cancer. Currently, two fluorescent probes for HO-1 have been designed based on the catalytic activity of HO-1, in which the probes serve as a substrate, so NADPH is required to enable the detection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!