A 6-year-old, mixed breed, intact male dog showed signs of left carpal joint swelling and weakness of the forelimbs one month before presentation. The symptoms gradually progressed to bilateral carpal and tarsal joint swelling and tetraparalysis. There were a number of radiographically identified lytic-proliferative bone lesions noted on the axial skeleton. Hypertrophic osteopathy of the metacarpi and all distal long bones was also evident. Because of the deteriorating quality of life and guarded prognosis, the patient was euthanized and a complete necropsy was performed. Renal cell carcinoma, with metastasis to the lung, thoracic vertebrae, ribs, and the right adrenal gland, was diagnosed. To our knowledge, renal cell carcinoma with bone metastases and hypertrophic osteopathy has not been reported in dogs.
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Article Synopsis
- Adult-onset Still's disease (AOSD) is a rare inflammatory condition that includes symptoms like daily fevers, joint pain, skin rashes, and spleen enlargement, often requiring tests to rule out blood cancers.
- A case study of a 38-year-old man revealed symptoms such as fatigue, high fever, night sweats, and skin rashes, leading to extensive testing, including CT and PET/CT scans that showed enlarged lymph nodes and high metabolic activity in his spleen and bone marrow.
- Ultimately, biopsies of the lymph node and bone marrow showed signs of hyperreactivity but no cancer, confirming AOSD as a diagnosis of exclusion, particularly when high ferritin levels and systemic symptoms are present
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