AI Article Synopsis
- Changes in the extracellular matrix are linked to heart remodeling, and this study focused on how the serum concentration of procollagen type I propeptide (PIP) correlates with outcomes in heart failure patients.
- A total of 111 patients with decompensated heart failure were analyzed, considering death and readmission rates as primary outcomes.
- Findings revealed that higher PIP levels were associated with greater risks of death and readmission, suggesting that PIP could serve as a valuable predictive marker for heart failure prognosis.
Article Abstract
Background: Changes in extracellular matrix are recognized as a contributing factor in the cardiac remodeling process. Several studies have addressed the value of turnover markers of collagen as predictors of death or new heart failure episodes. The aim of the present study was to evaluate the relationship between peripheral serum concentration of propeptide of procollagen type I (PIP) and outcomes in patients with decompensated heart failure.
Methods: A total of 111 patients admitted to our Unit between September 2000 and May 2003 for decompensated heart failure were analyzed. Death from any cause or due to heart failure and readmission were considered primary endpoints.
Results: The mean PIP concentration was 80.84+/-36.40 ng/mL. The PIP serum level was significantly higher among those patients who suffered some endpoint during follow-up (88.12+/-37.31 ng/mL vs 73.13+/-34.06 ng/mL; p=0.029). Twenty-five (22.52%) of the 111 patients died during the 21 months of follow-up, and 54 (48.6%) were readmitted with new bouts of heart failure. Using Cox proportional hazards regression analyses, serum PIP levels, systolic dysfunction, and diabetes mellitus were identified as independent predictors of death. Serum PIP levels, age, and sex were independent predictors of new heart failure episodes and readmission.
Conclusion: A single serum measurement of PIP seems to have prognostic value in patients with decompensated heart failure. Accordingly, patients with higher values of PIP at decompensation are at a higher risk of death or readmission during follow-up.
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| http://dx.doi.org/10.1016/j.ejim.2006.09.014 | DOI Listing |
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