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Re-sensitization of imipenem-resistant Pseudomonas aeruginosa and restoration of cephalosporins susceptibility in Enterobacteriaceae by recombinant Esterase B.
Lett Appl Microbiol
December 2024
Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok 10210, Thailand.
Article Synopsis
- Sphingobium sp. SM42 Esterase B (EstB) is an enzyme that helps break down dibutyl phthalate and enhances the effectiveness of certain antibiotics by modifying cephalosporins.
- A similar estB gene found in Pseudomonas aeruginosa suggests that it may have been transferred between bacteria.
- Introducing EstB into the periplasm of various Gram-negative bacteria, including P. aeruginosa and E. coli, increases their susceptibility to crucial antibiotics like carbapenems and cephalosporins, potentially overcoming antibiotic resistance.
Mutant prevention concentrations, resistance evolution dynamics, and mechanisms of resistance to imipenem and imipenem/relebactam in carbapenem-susceptible isolates showing ceftazidime/avibactam resistance.
Antimicrob Agents Chemother
December 2024
Servicio de Microbiología and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.
carbapenemase (KPC) variants selected during ceftazidime/avibactam treatment usually develop susceptibility to carbapenems and carbapenem/β-lactamase inhibitors, such as imipenem and imipenem/relebactam. We analyzed imipenem and imipenem/relebactam single-step mutant frequencies, resistance development trajectories and differentially selected resistance mechanisms using two representative isolates that had developed ceftazidime/avibactam resistance during therapy (ST512/KPC-31 and ST258/KPC-35). Mutant frequencies and mutant prevention concentrations were measured in Mueller-Hinton agar plates containing incremental concentrations of imipenem or imipenem/relebactam.
View Article and Find Full Text PDFAntimicrobial Resistance Trends and Epidemiological Characteristics of Isolates from Intra-Abdominal Infections in China: A 6-Year Retrospective Study (2017-2022).
Surg Infect (Larchmt)
November 2024
Research Institute of General Surgery, The Jinling School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Antimicrobial resistance represents a continuing threat to the health of patients with intra-abdominal infections (IAIs). This study aimed to provide clinicians with guidance to optimize antibiotic therapy. The clinical data and antibiotic susceptibility results of pathogens from patients with IAIs from 2017 to 2022 were retrospectively collected.
View Article and Find Full Text PDFPrevalence of carbapenem-resistant (CRE) in Saudi Arabia: A systematic review and meta-analysis.
Saudi Pharm J
November 2024
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Article Synopsis
- * The analysis reviewed 69 eligible studies out of 787 records and found significant resistance rates to key carbapenem antibiotics, with highest resistance reported for ertapenem (up to 34.2%) in recent years.
- * The findings highlight the urgent need for improved infection control strategies and ongoing surveillance to combat rising antibiotic resistance and protect public health.
This retrospective study, conducted over five years, aimed to assess the bacteriological profile of nosocomial pneumonia, the antibiotic resistance of isolated bacteria, and changes in these parameters over time. The analysis reviewed 660 samples from the microbiology department at the Military Hospital of Avicenne in Marrakech, Morocco, covering the period from January 1, 2017, to December 31, 2021. Among these samples, 303 microorganisms were identified from 251 specimens, confirming diagnoses of nosocomial pneumonia.
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