Sibudu Cave in KwaZulu-Natal, South Africa, has a long Middle Stone Age (MSA) sequence with good organic preservation. The uppermost MSA sequence includes industries attributed to the final and late MSA and the Howiesons Poort. Below the Howiesons Poort are two layers containing some thin, bifacial lanceolate points, mostly in the form of distal and proximal fragments. These double-pointed foliates are the fossile directeur of the Still Bay Industry, and importantly, this Sibudu industry provides confirmation that the Still Bay predates the Howiesons Poort Industry. Technologically, the points from Sibudu are comparable to those from other South African sites with Still Bay occurrences (e.g., Blombos Cave and Hollow Rock Shelter). Although dating of the Sibudu Still Bay is preliminary, its age falls within the range of that at Blombos. For the past two decades, archaeologists have rejected the idea of a Still Bay Industry occurring outside of the Western Cape, but the Still Bay at Sibudu shows that this industry was, indeed, geographically widespread.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jhevol.2007.01.002 | DOI Listing |
Int J Biol Macromol
January 2025
College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, Shandong Province, China; Sanya Oceanographic Institute, Ocean University of China, Floor 7, Building 1, Yonyou Industrial Park, Yazhou Bay Science & Technology City, Sanya, Hainan Province, China. Electronic address:
Rapid control of hemorrhage is vital in first-aid and surgery. As representative of emergency hemostatic materials, inorganic porous materials achieve rapid hemostasis through concentrating protein coagulation factors by water adsorption to accelerate the coagulation reaction process, however their efficacy is often limited by the insufficient contact of material with blood and the lack of blood clot strength. Herein, we report an ultrafast dispersing and in situ gelation sponge (SG/DB) based on anchoring interface effect for hemorrhage control using freeze drying method after mixing fish scale gel (SG) and tert-butyl alcohol (TBA) pre-crystallized diatom biosilica (DB).
View Article and Find Full Text PDFPest Manag Sci
January 2025
School of Life Science, Anhui Agricultural University, Hefei, China.
Background: Previously, eight new alkaloids were obtained from the fermentation extract of termite-associated Streptomyces tanashiensis BYF-112. However, genome analysis indicated the presence of many undiscovered secondary metabolites in S. tanashiensis BYF-112.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Research and Development Center of Optoelectronic Hybrid IC, Guangdong Greater Bay Area Institute of Integrated Circuit and System, Guangzhou 510535, China.
Short-wave infrared (SWIR) imaging has a wide range of applications in civil and military fields. Over the past two decades, significant efforts have been devoted to developing high-resolution, high-sensitivity, and cost-effective SWIR sensors covering the spectral range from 0.9 μm to 3 μm.
View Article and Find Full Text PDFBioorg Chem
January 2025
School of Biotechnology and Key Laboratory of Industrial Biotechnology of Education, School of Biotechnology, Jiangnan University, Wuxi 214122 China. Electronic address:
Achieving enzyme catalysis at high substrate concentrations is a substantial challenge in industrial biocatalysis, and the role of glycosylation in post-translational modifications that modulate enzyme substrate inhibition remains poorly understood. This study provides insights into the role of N-glycosylation in substrate inhibition by comparing the catalytic properties of d-lactonohydrolase (d-Lac) derived from Fusarium moniliforme expressed in prokaryotic and eukaryotic hosts. Experimental evidence indicates that recombinant d-Lac expressed in Pichia pastoris (PpLac-WT) exhibits higher hydrolysis rates at a substrate concentration of 400 g/L, with reduced substrate inhibition and enhanced stability compared to the recombinant d-Lac expressed in Escherichia coli (EcLac-WT).
View Article and Find Full Text PDFBiomaterials
January 2025
Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, 518107, China; School of Medicine, Hangzhou City University, Hangzhou, 310015, China; Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo, 315040, China. Electronic address:
T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by the loss of tumor surface antigens and inactivation in acidic tumor microenvironment (TME). Herein, we developed a bifunctional immunomodulator (MO@NAL) by loading ovalbumin (OVA; model antigen) mRNA (mOVA) onto lysozyme-coated layered double hydroxide nano-aluminum adjuvant (NA). The NA's inherent alkalinity effectively neutralizes the excess acid within the TME and suppresses regulatory T cells, creating a favorable microenvironment to enhance cytotoxic T cell infiltration and activation in tumors.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!