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Autonomic nervous system and secretion across the intestinal mucosal surface. | LitMetric

Autonomic nervous system and secretion across the intestinal mucosal surface.

Auton Neurosci

Department of Neuroscience, 333 West 10th Avenue, The Ohio State University, Columbus, OH 43210, USA.

Published: April 2007

AI Article Synopsis

Article Abstract

Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-hydroxytryptamine (5-HT) and activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also trigger reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936976PMC
http://dx.doi.org/10.1016/j.autneu.2007.02.001DOI Listing

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