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Compressing human brain activity for studying brain function.
PLoS Biol
December 2024
Montréal Neurological Institute, McGill University, Montréal, Canada.
Due to its complexity and size, the optimal scale or level at which to describe the brain remains an open question in neuroscience. A new study published in PLOS Biology shows that simplifying complex brain recordings makes them more useful for studying brain function.
View Article and Find Full Text PDFPrecision neuroimaging reveals corticostriatal mapping.
J Neurophysiol
December 2024
Department of Psychology and NeuroscienceTemple University, Philadelphia, Pennsylvania, United States.
Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation.
JAMA Neurol
December 2024
Laboratory of Neuroimaging of Aging, University of Geneva, Geneva, Switzerland.
Article Synopsis
- * Concerns are raised about purely biological definitions being used in clinical settings, especially since many biomarker-positive but cognitively normal individuals may never develop symptoms, complicating diagnosis and patient understanding.
- * The authors advocate for a combined clinical-biological definition of AD that accommodates at-risk and presymptomatic stages, emphasizing the need for caution in diagnosing AD without fully understanding the implications for patients.
Patterns of Brain Maturation in Autism and Their Molecular Associations.
JAMA Psychiatry
December 2024
Department of Child and Adolescent Psychiatry, University Hospital Goethe University, Frankfurt am Main, Germany.
Importance: In the neurotypical brain, regions develop in coordinated patterns, providing a fundamental scaffold for brain function and behavior. Whether altered patterns contribute to clinical profiles in neurodevelopmental conditions, including autism, remains unclear.
Objectives: To examine if, in autism, brain regions develop differently in relation to each other and how these differences are associated with molecular/genomic mechanisms and symptomatology.
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