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| http://dx.doi.org/10.1016/j.advenzreg.2006.12.007 | DOI Listing |
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In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma.
Drug Deliv
December 2025
Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain.
Recent studies on head and neck squamous cell carcinoma (HNSCC) tumorigenesis have revealed several dysregulated molecular pathways. The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in HNSCC, making it an attractive target for therapies. PHT-427 is a dual inhibitor of PI3K and the mammalian target of AKT/PDK1.
View Article and Find Full Text PDFDecoding the general role of tRNA queuosine modification in eukaryotes.
Sci Rep
January 2025
Department of Molecular Evolution, Centro de Astrobiología (CAB), CSIC-INTA, Carretera de Ajalvir Km 4, Torrejón de Ardoz, 28850, Madrid, Spain.
Transfer RNA (tRNA) contains modified nucleosides essential for modulating protein translation. One of these modifications is queuosine (Q), which affects NAU codons translation rate. For decades, multiple studies have reported a wide variety of species-specific Q-related phenotypes in different eukaryotes, hindering the identification of a general underlying mechanism behind that phenotypic diversity.
View Article and Find Full Text PDFThe Vacuole Lipid Droplet Contact Site vCLIP.
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December 2024
Institute of Cell Dynamics and Imaging, University of Münster, Münster, Germany.
Lipid droplets frequently form contact sites with the membrane of the vacuole, the lysosome-like organelle in yeast. These vacuole lipid droplet (vCLIP) contact sites respond strongly to metabolic cues: while only a subset of lipid droplets is bound to the vacuole when nutrients are abundant, other metabolic states induce stronger contact site formation. Physical lipid droplet-vacuole binding is related to the process of lipophagy, a lipid droplet-specific form of microautophagy.
View Article and Find Full Text PDFToxicity of microplastics and nano-plastics to coral-symbiotic alga (Dinophyceae Symbiodinium): Evidence from alga physiology, ultrastructure, OJIP kinetics and multi-omics.
Water Res
December 2024
School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, 524088, China; Analyzing and Testing Center, Guangdong Ocean University, Zhanjiang, 524088, China; Analytical and Testing Center for Ocean in Western of Guangdong Province, Guangdong Provincial Observation and Research Station for Tropical Ocean Environment in Western Coastal Water, Guangdong Ocean University, Zhanjiang, 524088, China. Electronic address:
Article Synopsis
- Corals rely on a symbiotic relationship with the algae Symbiodinium spp., which is essential for the productivity of coral reefs.
- Recent studies have highlighted that microplastics (MPs) and nano-plastics (NPs) can disrupt this relationship, leading to coral bleaching.
- This research examined how MPs and NPs affect the growth and cellular health of Symbiodinium, revealing that these plastics cause significant oxidative stress and cellular damage, ultimately impairing photosynthesis and disrupting metabolic processes in the algae.
Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays.
Methods Mol Biol
December 2024
Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
Lipid transfer proteins (LTPs) are specialized proteins that convey specific lipids across the cytosol to regulate the lipid composition of organelles and the plasma membrane. Quantifying to which extent these LTPs recognize and transfer various lipid species and subspecies is of prime interest to define their cellular role(s). Here, we describe how to measure in vitro the relative affinity of Osh6p, a yeast phosphatidylserine (PS)/phosphatidylinositol 4-phosphate (PI(4)P) exchanger belonging to the oxysterol-binding protein(OSBP)-related protein (ORP) family, for PS and phosphoinositide subspecies.
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