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Burden of silicosis based on the Global Burden of Disease Study 2021: trend analysis of incidence, mortality, and disability-adjusted life years, and projections for the next 30 years.
J Thorac Dis
February 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Background: Silicosis, an occupational disease caused by chronic silica exposure, has a high global burden and limited treatment options. This study analyzed the epidemiological trends and future projections of silicosis based on data from the Global Burden of Disease (GBD), aiming to provide data support for public health interventions.
Methods: We extracted and analyzed the data on the incidence, mortality, and disability-adjusted life years (DALYs) of silicosis, as well as the age-standardized rate (ASR) of silicosis from the GBD Study 2021.
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
Sci Transl Med
March 2025
Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
Interstitial lung disease (ILD) consists of a group of immune-mediated disorders that can cause inflammation and progressive fibrosis of the lungs, representing an area of unmet medical need given the lack of disease-modifying therapies and toxicities associated with current treatment options. Tissue-specific splice variants (SVs) of human aminoacyl-tRNA synthetases (aaRSs) are catalytic nulls thought to confer regulatory functions. One example from human histidyl-tRNA synthetase (HARS), termed HARS because the splicing event resulted in a protein encompassing the WHEP-TRS domain of HARS (a structurally conserved domain found in multiple aaRSs), is enriched in human lung and up-regulated by inflammatory cytokines in lung and immune cells.
View Article and Find Full Text PDFBeyond the Lungs: A Case Report of Disseminated Tuberculosis With Multisystem Involvement.
Cureus
February 2025
Internal Medicine, Hospital da Senhora da Oliveira, Guimarães, PRT.
Tuberculosis (TB) is an infectious disease caused by acid-fast bacillus pertaining to the complex. Pulmonary TB is the most common presentation, resulting either from primary infection or reactivation of latent disease. In rare cases, wide dissemination of can occur, usually by hematogenous or lymphatic route, leading to multiorgan involvement and potentially life-threatening conditions known as disseminated TB.
View Article and Find Full Text PDFCorrigendum to "Shikonin modulates activated fibroblast apoptosis in silicosis fibrosis via the PI3K/Akt signaling pathway: A network pharmacology approach" [Toxicology and Applied Pharmacology. 2025 Feb, 495, 117236].
Toxicol Appl Pharmacol
March 2025
School of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, Ningxia 750000, China. Electronic address:
Silicosis related pleural effusion: black spots in pleura.
BMJ Case Rep
March 2025
Department of Radiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
A male patient in his 70s, who had previously worked as a bricklayer, presented with worsening shortness of breath on exertion and cough for 6 months. He had lost weight, and a respiratory examination suggested a right pleural effusion. Routine evaluation was unremarkable.
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