Toxoplasmosis is a frequent cause of infection of the central nervous system (CNS) in patients with acquired immunodeficiency syndrome. Computed tomography (CT) usually shows solitary or multiple parenchymal lesions, which are most often located in the cortex, the juxtacortical white matter and the basal ganglia. The authors describe a 30-year-old immunocompromised Haitian woman with pathologically proven CNS toxoplasmosis who presented with hydrocephalus and prominence of the choroid plexus; there was no evidence of focal parenchymal lesions in contrast-enhanced CT scans. An autopsy revealed diffuse destruction of the ependyma of the lateral, the third and the fourth ventricles. Necrosis was evident, and the periventricular tissues and the choroid plexus were infiltrated with neutrophils and macrophages. Pseudocysts of Toxoplasma were identified near the ventricular surface.
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