We report the case of a premature newborn (gestational age 33 weeks) with congenital glaucoma. After a trabeculotomy high intraocular pressure persisted, leading to adjuvant treatment with timolol and--when the infant was 3 weeks old--with brimonidine. After the first application of topical brimonidine the infant developed such severe apnoeic spells that intubation and temporary ventilation were necessary. A review of the literature reveals that when used in young infants brimonidine eye drops can potentially have toxic effects on the central nervous system (e.g. respiratory depression). The use of topical brimonidine is therefore not advised in this age group.
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Article Synopsis
- - Glaucoma, a condition that damages retinal ganglion cells (RGC), was studied to evaluate the neuroprotective effects of brimonidine, which can lower intraocular pressure and potentially protect these cells.
- - In the experiment, 41 mice had their optic nerves crushed and were divided into three groups receiving different treatments: saline, topical brimonidine, or a combination of topical and intraperitoneal (IP) brimonidine injections.
- - Results showed that mice receiving both topical and IP brimonidine had significantly higher RGC survival rates compared to those receiving only saline or just topical brimonidine.
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