Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ncprheum0434 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feeding disruptions lead to a significant increase in disease modules in adult mice.
Heliyon
January 2025
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Feeding disruption is closely linked to numerous diseases, yet the underlying molecular mechanisms remain an important but unresolved issue at the molecular level. We hypothesize that, at the network level, dietary disruptions can alter gene co-expression patterns, leading to an increase in disease-associated modules, and thereby elevating the likelihood of disease occurrence. Here, we investigate this hypothesis using transcriptomic data from a large cohort of adult mice subjected to feeding disruptions.
View Article and Find Full Text PDFStimuli-responsive nanoscale drug delivery system for epilepsy theranostics.
Acta Biomater
January 2025
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences and School of Basic Medical Sciences, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:
Epilepsy is a common neurological disease characterized by distinct pathological changes in the epileptogenic zone. Antiseizure drugs (ASDs) are widely used as the primary treatment for epilepsy. To improve the efficiency of ASDs medication, stimuli-responsive nanoscale drug delivery systems (nanoDDSs), triggered by either endogenous or exogenous factors, have been developed and been considered as a noninvasive and spatial-temporal approach to epilepsy theranostics.
View Article and Find Full Text PDFSkull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance.
Cell Death Dis
January 2025
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P.R. China.
The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize skull bone marrow and SMCs by detailing the anatomical structures adjacent to the skull, the differences between skull and peripheral bone marrow, mainstream animal processing methods, and the role of skull bone marrow in monitoring various CNS diseases.
View Article and Find Full Text PDFNavigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos.
Syst Biol Reprod Med
December 2025
College of Medicine, Department of Basic Sciences, Roseman University of Health Sciences, Las Vegas, NV, USA.
Cryopreservation, the use of very low temperatures to preserve structurally intact living cells and tissues, has seen exponential growth in the field of fertilization (IVF). In the last decade, cryopreservation of embryos and freeze-all protocols have become an essential aspect and a prerequisite for a successful IVF outcome. Moreover, vitrification, which is a fast and safe cryopreservation method, has proved to be an effective choice for cryopreserving gametes and embryos.
View Article and Find Full Text PDFEffect of ligamentum teres uteri preservation in laparoscopic high hernia sac ligation in children with indirect inguinal hernia.
World J Gastrointest Surg
January 2025
Department of Pediatric Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
Background: Routinely separating the ligamentum teres uteri (LTU) intraoperatively remains an unresolved issue for female children undergoing surgery for indirect inguinal hernia (IIH).
Aim: To identify the effect of LTU preservation in laparoscopic high hernia sac ligation (LHSL) in children with IIH.
Methods: The participants were 100 female children with unilateral IIH admitted from April 2022 to January 2024 to the Pediatric Surgery Department of Zhangzhou Municipal Hospital of Fujian Province.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!