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The adenomatoid odontogenic tumor (AOT) is a benign, non-invasive lesion with a slow but progressive growth. This tumor has three variants: follicular, extrafollicular, and peripheral. The extrafollicular type is an intraosseous lesion that is not associated with unerupted teeth. Radiographically, it appears as a well-defined, unilocular, round or ovoid radiolucency with multiple, small, irregular radiopaque foci. Microscopically, it is characterized by nodules of cuboidal or columnar epithelial cells that form nests, rosette or duct-like structures (with minimal stromal connective tissue), and acellular calcifications. This article presents the case of a 35-year-old man with a lesion on the anterior mandible. Clinical and radiographic features indicate that this lesion is an extrafollicular variant of AOT.
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Article Synopsis
- Adenoid ameloblastoma (AA) is a rare but locally aggressive benign tumor derived from dental tissue remnants, and it was recently classified as a new type of odontogenic lesion by the WHO in 2022.
- This tumor behaves more aggressively than similar types, presenting as a painless jaw swelling with a high recurrence rate and local invasiveness, and exhibits unique histopathological features such as a cribriform pattern and differential marker expression.
- Due to its complex nature and unclear origins, AA requires thorough clinical evaluation and customized treatment approaches to manage recurrence and improve patient outcomes, with the latest research contributing to its understanding post-classification.
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