AI Article Synopsis
- The study looked at coeliac disease in high-risk Sudanese children, focusing on symptoms, diagnosis, and serological markers from 2001 to 2002.
- Out of 80 children with symptoms like poor appetite and weight loss, 22.5% were diagnosed with coeliac disease.
- The results showed a variety of intestinal damage in biopsied children, but the extent of damage didn't correlate with symptoms like diarrhea or anemia.
- All diagnosed children improved on a gluten-free diet.
Article Abstract
Our prospective hospital-based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high-risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months-18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 (22.5%). Antigliadin antibodies (AGA-IgG, AGA-IgA or both) were high in 44; endomysial antibody retest was high in 30. Guardians of 12 children refused consent for biopsy. The other 18 were biopsied: 5 had total villous atrophy, 8 subtotal and 5 partial. All improved with gluten-free diet. Degree of villous atrophy did not correlate with diarrhoea duration or severity, anaemia severity or serological titres.
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