AI Article Synopsis
- The study highlights the high failure rates of eradicating Helicobacter pylori using a common three-antibiotic regimen (amoxicillin, clarithromycin, and metronidazole), prompting the need for alternative treatments.
- A total of 72 H. pylori isolates from patients with gastritis and chronic dyspepsia were tested for antibiotic sensitivity using standardized methods.
- The findings revealed 100% resistance to metronidazole, along with varying resistance rates for other antibiotics, with fluoroquinolones showing the lowest resistance levels, suggesting they could be potential substitutes in treatment.
Article Abstract
Helicobacter pylori eradication using the three antibiotic regimen of amoxicillin, clarithromycin and metronidazole often fails, making it imperative to find substitutes. The following study made use of 72 H. pylori isolates derived from pyloric antrum mucosa biopsies of gastritis and chronic dyspepsia patients treated at the Cipto Mangunkusumo National General Hospital and three private hospitals in Jakarta. Testing for H. pylori sensitivity to various antimicrobials was conducted using the disk diffusion method (Kirby Bauer) and procedures determined by the Clinical and Laboratory Standards Intitute (CLSI)/NCCLS. The resistance rates of the isolates were 100% for metronodazole, 27.8% for clarithromycin, 19.4% for amoxicillin, 6.9% for ciprofloxacin, norfloxacin and ofloxacin, 2.8% for sparfloxacin and gatifloxacin, and 1.4% for levofloxacin and moxifloxacin. Fluoroquinolons have the lowest resistance compared to amoxicillin, clarithromycin and metronidazole.
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